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dc.contributor.authorHillier, Troy
dc.contributor.otherQueen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))en
dc.date.accessioned2019-08-02T15:51:27Z
dc.date.available2019-08-02T15:51:27Z
dc.identifier.urihttp://hdl.handle.net/1974/26454
dc.description.abstractBackground: A moderate amount of time spent in the sun has been hypothesized to be protective against several internal cancers, including breast cancer. This project summarized and synthesized existing literature on this topic and identified sources of heterogeneity (manuscript 1). Secondly, this project examined this relationship using data from Canadian prospective cohort studies (manuscript 2). Methods: First, a meta-analysis of case-control and cohort studies was conducted to investigate the relationships between time spent in the sun, and ambient UVR with breast cancer risk. Heterogeneity was quantified with I-squared statistics and potential sources were investigated through subgroup analyses. Second, a prospective cohort study was conducted using self-reported questionnaire data from the Alberta Tomorrow Project (ATP) and Quebec’s CARTaGENE (CaG) that was linked to cancer registry (ATP) and administrative (CaG) data. Cox proportional hazards models, using age as the time-scale were employed to investigate the association between solar UVR exposure and pre- and postmenopausal breast cancer with control for relevant confounders. Results: In a dose-response meta-analysis, spending 1-2 hours in the sun per day was protective against breast cancer, with no additional benefit for >2 hours per day. Few studies performed analyses stratified by menopausal status. In manuscript 2, a suggestive protective effect for greater than 2 hours spent in the sun per day during summer months was observed in postmenopausal women only. No significant interactions between time spent in the sun and ambient UVR, vitamin D intake, or skin tone were observed.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCanadian thesesen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada*
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreement*
dc.rightsIntellectual Property Guidelines at Queen's University*
dc.rightsCopying and Preserving Your Thesis*
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.*
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectbreast canceren_US
dc.subjectepidemiologyen_US
dc.subjectmeta-analysisen_US
dc.subjectprospectiveen_US
dc.subjectultraviolet radiationen_US
dc.titleSolar Ultraviolet Radiation and Breast Cancer Risken_US
dc.typethesisen
dc.description.degreeMaster of Scienceen_US
dc.contributor.supervisorKing, Will
dc.contributor.departmentPublic Health Sciencesen_US
dc.embargo.termsRestriction of this thesis for a period of 2 years is being sought to allow time for publication of the two manuscripts it contains. An email asking for this permission will be sent to thesis@queensu.ca from Dr. King.en_US
dc.embargo.liftdate2024-07-29T14:07:10Z
dc.embargo.liftdate2024-08-02T03:15:08Z


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Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada
Except where otherwise noted, this item's license is described as Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada