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    Browsing Biology, Department of by Author "Young, Paul G."

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      • A functional analysis of mitotic tyrosine phosphatases by site-directed mutagenesis 

        Stobbe, Stephanie (2013-09-12)
        In Schizosaccharomyces pombe mitosis is initiated when Cdc25 tyrosine phosphatase dephosphorylates Cdc2 (Cdk1) and in turn Cdc2 kinase phosphorylates mitotic targets. Cdc2 is thought to phosphorylate and further activate ...
      • Genetic Suppression of Stress Sensitivity Following Loss of SSPI (CAMKK) in Schizosaccharomyces Pombe 

        Al Dandan, Hussain (2014-01-27)
        Loss of the ssp1 protein kinase (CAMKK) gene results in stress sensitivity, cell elongation, slow growth and in some cases cell cycle arrest. In order to identify new components of the ssp1 stress response pathway, a ...
      • Homo and hetero-dimerization studies of two Zn(II)2Cys6 transcription factors in fission yeast 

        Ferrant, Harriet Ann (2012-07-06)
        This thesis presents a strategy designed to determine how Thi1 and Thi5 may differentially regulate thiamine production and the vegetative and sexual life cycles in fission yeast. Fission yeast cells regulate the cell ...
      • Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast 

        Yimit, Askar (2016-04-07)
        In fission yeast, Schizosaccharomyces pombe, tyrosine dephosphorylation of p34cdc2 is required for mitotic initiation and this reversible tyrosine phosphorylation plays a crucial role in the regulation of the cell cycle. ...
      • Regulation of the Cdc25 mitotic inducer following replication arrest and DNA damage 

        Frazer, Corey Thomas (2011-06-20)
        Dephosphorylation of the Cdc2 kinase by the Cdc25 tyrosine phosphatase is the universally conserved trigger for mitotic entry. Cdc25 is also the point of convergence for checkpoint signaling pathways which monitor the ...
      • The Role of Schizosaccharomyces Pombe SER/THR Kinase in Growth, Stress Response and Nutrient Deprivation 

        Freitag, Silja I. (2012-01-24)
        Continuous sensation and reaction to environmental fluctuations is especially critical to the survival of unicellular organisms. Stress response mechanisms are essential for cells during the vegetative and sexual life ...
      • Srk1 kinase suppresses mitosis in response to heat stress in fission yeast 

        Chandrashekhar, Megha (2011-08-10)
        Fission yeast Srk1 kinase is essential for cellular responses to extracellular stimuli. It is activated downstream of the MAPK Spc1 and participates in controlling mitotic entry by directly phosphorylating and inhibiting ...

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