Translational Medicine Graduate Theses
Recent Submissions
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The Neuromechanical Mechanisms of Exertional Dyspnea Across the Continuum of Chronic Obstructive Pulmonary Disease (COPD) Severity
Rationale: Patients with chronic obstructive pulmonary disease (COPD) have burdensome exertional dyspnea (breathlessness) during exercise, which is associated with an elevated inspiratory neural drive (IND). The neurophysiologic ... -
Exploring the contribution of natural killer cell TGFβ signaling to pulmonary vascular development and the pathogenesis of hypoxia-induced pulmonary hypertension
Background: Proper immune functioning is crucial for lung development and vascular stability; deviations to these processes may lead to complications, including bronchopulmonary dysplasia (BPD) and pulmonary arterial ... -
PROMOTING EVIDENCE-BASED ASTHMA DIAGNOSIS AND SURVEILLANCE USING ELECTRONIC TOOLS
Background: In Canada, asthma is one of the most common chronic conditions. It is estimated that approximately 3.8 million people in Canada suffer from asthma. The majority of asthma diagnoses and care take place in primary ... -
PKA INHIBITION DURING FGD1 DYSREGULATION UNMASKS A DOMINANT ROLE FOR RHOGDI⍺ IN COORDINATING THE ANGIOGENIC ACTIONS OF CDC42
Angiogenic sprouting, the growth of blood vessels from pre-existing vasculature, underlies normal development, but its dysregulation contributes to the pathologies of life-threatening medical conditions, including cancer ... -
EVALUATING THE GASTROINTESTINAL MICROBIOTA OF HOSPITALIZED NEONATES USING CULTUROMICS AND METAGENOMICS
Background: The developing gastrointestinal microbiota (GIM) of neonates plays an important role in long and short-term health. ‘Culturomics’, the use of specialized media in conjunction with metagenomics has the potential ... -
FEMALE RISK FACTORS FOR POST-INFARCTION DEPRESSION AND ANXIETY: THE FRIDA STUDY
Cardiovascular disease (CVD) is the leading global cause of mortality, with ischemic heart disease causing the majority of CV deaths. CVD is traditionally considered to be most prominent in males. Yet, female patients ... -
Critical Role of Electron Leak from Mitochondrial Electron Transport Chain Complex I in Oxygen Sensing in the Rabbit Ductus Arteriosus
Background: The ductus arteriosus (DA) connects the pulmonary trunk to the descending thoracic aorta, allowing placentally oxygenated blood to bypass the non-ventilated fetal lungs and enter the systemic circulation. The ... -
Improving Detection of Work-related Asthma: Validation of the Work-related Asthma Screening Questionnaire (Long-Version)
Background: The Work-related Asthma Screening Questionnaire (Long-version) (WRASQ(L))TM is designed to screen for work-related asthma (WRA) in primary care and specialist settings. Purpose: The purpose of this study was ... -
Proteomic investigation of vulnerable atherosclerotic carotid plaque composition using novel 'cytof' hyperion imaging system
Atherosclerosis, the forerunner of cardiovascular diseases, is regarded as the main cause of mortality, with an age-related rise in prevalence. It is defined as a chronic immune-mediated inflammatory illness that causes a ... -
Effects of Phosphodiesterase Variants on Angiogenic Functions of Vascular Endothelial Cells
Angiogenesis, the biological process of new vessel growth from already existing vasculature, occurs physiologically and pathologically. Previous studies have linked insufficient angiogenic activity to ischemic disease ... -
Frequency Analysis of the QRS Complex for Implantable Cardioverter Defibrillator Patients for Risk Stratification
Background: Sudden cardiac death (SCD) is one of the leading causes of cardiovascular death in North America. A metric called Layered Symbolic Decomposition frequency (LSDf) has been found to independently predict risk of ... -
Liver Transplant Wait-list Trends in Young American Adults
Background: Cirrhosis refers to end stage liver disease and it is the final common pathway for all chronic liver diseases (CLDs). Recent data illustrates that mortality secondary to cirrhosis is increasing in the United ... -
HIGH-DOSE WEEKLY CARFILZOMIB, CYCLOPHOSPHAMIDE, AND DEXAMETHASONE IN THE TREATMENT OF PATIENTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA – EXPLORING THE FINANCIAL COST AND RARE SIDE-EFFECTS
Multiple myeloma Multiple myeloma (MM) is a malignant disorder of clonal plasma cells based in the bone marrow that leads to devastating symptoms including renal failure, hypercalcemia, anemia, and fractures. Treatment ...
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