Show simple item record

dc.contributor.authorBanasikowski, Tomek J.
dc.contributor.otherQueen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))en
dc.date2012-08-12 15:51:00.467en
dc.date.accessioned2012-08-13T21:57:11Z
dc.date.available2015-11-01T09:00:08Z
dc.date.issued2012-08-13
dc.identifier.urihttp://hdl.handle.net/1974/7365
dc.descriptionThesis (Ph.D, Neuroscience Studies) -- Queen's University, 2012-08-12 15:51:00.467en
dc.description.abstractThe behavioral effects of drugs that act on the brain’s dopamine (DA) system change with repeated exposure to the drug. Antipsychotic drugs, that block DA receptors, produce progressively greater effects on behavior with repeated testing. For example, rats repeatedly treated with a low dose of the D2 receptor-preferring antagonist haloperidol do not initially exhibit catalepsy, a response quantified by time spent on a horizontal bar without active movement. However, with repeated drug-environment pairings animals show a reduction in exploration and increases in catalepsy. The current thesis examined the drug-environment relationship in catalepsy sensitization, and how different DA receptor subtypes control this phenomenon. Treatment with a D2, but not D3 or D1-like receptor-preferring antagonist produced catalepsy sensitization. Catalepsy sensitization developed in one test environment did not transfer to another environment. Similarly, rats with a history of haloperidol treatments outside of the test environment (unpaired group) did not exhibit significant catalepsy when given haloperidol for the first time prior to catalepsy testing. Previous exposure to the catalepsy test environment led to a more rapid development of catalepsy sensitization. Thus, drug-environment interaction is critical for the development and expression of catalepsy sensitization. Rats previously given haloperidol and tested with saline in the drug paired environment exhibited conditioned catalepsy. The acquisition of conditioned catalepsy is dependent on D1-like receptors, while its expression is dependent on D3 receptors. Conditioned catalepsy showed gradual day-to-day extinction with repeated saline treatment in the previously haloperidol-paired environment. Following extinction, the response to haloperidol in previously sensitized rats shifted from environment-specific to environment-independent suggesting that a putative haloperidol drug cue alone can elicit conditioned catalepsy. In summary, treatment with a D2, but not D1-like or D3 receptor-preferring antagonist in a particular test environment produces catalepsy sensitization, while acquisition of conditioned catalepsy is dependent on D1-like receptors, and its expression is dependent on D3 receptors. Importantly, the acquisition and expression of sensitization to haloperidol is conditional on the presence of drug-associated environmental stimuli. Our findings provide further insight into the current understanding of learning processes involved in the action of antipsychotic drugs and the dissociable effects of D1-like, D2 and D3 receptors controlling this phenomenon.en_US
dc.languageenen
dc.language.isoenen_US
dc.relation.ispartofseriesCanadian thesesen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectMOTIVATIONen_US
dc.subjectLEARNING AND MEMORYen_US
dc.subjectDOPAMINEen_US
dc.subjectSENSITIZATIONen_US
dc.subjectANTIPSYCHOTICSen_US
dc.subjectBEHAVIORAL NEUROSCIENCEen_US
dc.titleDOPAMINE D1-LIKE, D2 AND D3 RECEPTOR SUBTYPES IN CATALEPSY SENSITIZATION AND CONDITIONING IN RATS: IMPLICATIONS FOR MOTOR FUNCTION, MOTIVATION AND LEARNINGen_US
dc.typeThesisen_US
dc.description.restricted-thesisprotect any rights to commercial publicationen
dc.description.degreePh.Den
dc.contributor.supervisorBeninger, Richard J.en
dc.contributor.departmentNeuroscience Studiesen
dc.embargo.terms1825en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record