Show simple item record

dc.contributor.authorSmith, Justin
dc.contributor.otherQueen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))en
dc.date2012-08-15 11:57:28.915en
dc.date.accessioned2012-08-15T22:36:05Z
dc.date.available2012-08-15T22:36:05Z
dc.date.issued2012-08-15
dc.identifier.urihttp://hdl.handle.net/1974/7372
dc.descriptionThesis (Master, Chemistry) -- Queen's University, 2012-08-15 11:57:28.915en
dc.description.abstractDespite the prominent role played by open tubular columns in gas chromatography, they have enjoyed comparatively little success as supports for open tubular liquid chromatography (OTLC), owing to impractical channel diameters (3-5 μm) required to facilitate retention in the liquid phase. In an effort to circumvent the technical issues associated with such narrow diameters, columns with multiple parallel channels have been suggested as alternatives – to this end, micro-structured fibres (MSFs) have been proposed as supports for OTLC. Much research has been conducted using MSFs for chromatography in the Oleschuk group, and although some success has been achieved, performance has been continuously hindered by flow velocity variation among the channels stemming from differences in channel sizes (or channel variance) as well as differences in stationary phase coverage, which serve to degrade column efficiency. Recent efforts have focused on devising a novel method for assessing the channel variance of MSFs. This method seeks to determine hole tolerance through evaluation of the extent of band broadening that occurs when performing chromatography in the absence of a retentive mechanism. Using this method, a linear correlation between the relative standard deviation of the channel diameters and the amount of broadening was revealed. To supplement the results, computational fluid dynamics was employed to simulate fluid flow through multi-channel columns. The results of these simulations again provided a linear correlation between the RSD of the channel diameters and the extent of flow velocity variation among the channels.en_US
dc.languageenen
dc.language.isoenen_US
dc.relation.ispartofseriesCanadian thesesen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectMicro-structured Fibresen_US
dc.subjectOpen Tubular Liquid Chromatographyen_US
dc.titleCharacterization of Mobile Phase Flow Inhomogeneity in Micro-structured Fibres: Towards the Development of Multi-channel Supports for Open Tubular Liquid Chromatographyen_US
dc.typeThesisen_US
dc.description.degreeMasteren
dc.contributor.supervisorOleschuk, Richarden
dc.contributor.departmentChemistryen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record