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A Study of the Roles of Selected Arginine and Lysine Residues of TAFI in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex
Thrombin-activatable Fibrinolysis Inhibitor (TAFI) is a 60 kDa plasma protein that can be activated to the enzyme, TAFIa, by thrombin, plasmin or trypsin. TAFIa is a carboxypeptidase B-like enzyme that attenuates fibrinolysis. ...
CHARACTERIZATION OF TAFI ACTIVATION BY THE THROMBIN-THROMBOMODULIN COMPLEX
Once activated, protein C (PC) and thrombin-activable fibrinolysis inhibitor (TAFI) initiate anticoagulant and anti-fibrinolytic pathways, respectively. PC and TAFI are activated by the thrombin-thrombomodulin (TM) complex. ...