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Cdc42-Interacting Protein Family Adaptors Regulate Endocytosis, Membrane Trafficking, Migration, and Invasion in Cancer Cells
Timely and spatially controlled endosomal trafficking and signaling is important for cell proliferation, directed cell migration, and cell invasion, which are frequently misregulated in cancer cells. Cdc42-interacting ...
Apoliprotein(a)-Induced Apoptosis in Vascular Endothelial Cells
Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a risk factor for a variety of atherosclerotic disorders including coronary heart disease. In the current study, the investigators report that incubation of ...
Ice-binding proteins adsorb to their ligand via anchored clathrate waters
The main success of my thesis has been to establish the mechanism by which antifreeze proteins (AFPs) bind irreversibly to ice crystals, and hence prevent their growth. AFPs organize ice-like water on their ice-binding ...
p53 Regulates the Formation of Lamellipodia and Circular Dorsal Ruffles Through Caldesmon and PTEN
Vascular smooth muscle cell migration is a significant contributor to many aspects of heart disease, and specifically atherosclerosis. Tissue damage in the arteries can result in the formation of a fatty streak. Smooth ...
Characterization of a Newly Synthesized Cysteinyl Leukotriene 2 Receptor Selective Antagonist Using Cell Based β-arrestin and Vascular Ear Permeability Assays in Mice
(hCysLT2R) based on a β-galactosidase complementation system. The EC50 values for LTC4 and LTD4 are consistent with previous literature values determined based on radio-labelling affinity assays for hCysLT2R. Activity ...