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UNDERSTANDING THE MECHANISM OF MOTILITY OF THE HETERODIMERIC KINESIN-14 KAR3VIK1
The kinesin-14 Kar3 from Saccharomyces cerevisiae (Sc) is a C-terminal motor that forms a heterodimer with the kinesin-accessory protein Vik1. Although Vik1 possesses a typical kinesin motor domain (MD) fold, it lacks a ...
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ...
The interaction between Rad9 and Tousled-like kinase 1 in the cell cycle and the DNA damage response
Genomic integrity is preserved by checkpoints, which are signal transduction pathways that serve to delay cell cycle progression in the presence of DNA damage or replication stress. The heterotrimeric Rad9-Rad1-Hus1 (9-1-1) ...