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STRUCTURAL INSIGHTS INTO NOVEL MICROBIAL METALLOENZYMES
Metalloproteins represent a large portion of the total proteome. When bound to a protein a metal ion influences both protein stability and function through structural, catalytic or regulatory roles. Discovery of a metal ...
A Competition Study on Copper-binding Affinity of SCO protein
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water and contributes to the electrochemical gradient by translocating protons across the membrane. The SCO protein (for Synthesis of Cytochrome c Oxidase) ...
Calpain inhibitor design inspired by the natural inhibitor calpastatin
Calpains are cysteine proteases that depend on Ca2+ for activation. They have many roles in the cell; hence modifications of calpains or changes in their levels of activity can lead to altered physiological states. Thus, ...
GLUCOCORTICOID RECEPTOR (NR3C1) PROMOTER METHYLATION AS A CIRCULATING BREAST CANCER BIOMARKER AND ITS ROLE IN TAMOXIFEN SENSITIVITY
The glucocorticoid receptor (GR) binds glucocorticoids and transcriptionally regulates genes involved in immune response, cellular proliferation, and apoptosis. Previous work in our lab using MeDIP followed by qPCR found ...
SHP2/PTPN11 PROTEIN-TYROSINE PHOSPHATASE PROMOTES MAST CELL HOMEOSTASIS AND SYSTEMIC MASTOCYTOSIS
KIT receptor (CD117) is a receptor tyrosine kinase crucial for homeostasis of mast cells (MCs) in tissues and recruitment to sites of inflammation and tumors in response to its ligand Stem cell factor (SCF). Gain of function ...