Now showing items 1-6 of 6
Sequence and Structure Based Protein Folding Studies With Implications
As the expression of the genetic blueprint, proteins are at the heart of all biological systems. The ever increasing set of available protein structures has taught us that diversity is the hallmark of their architecture, ...
Regulation of the Gene Encoding Thrombin-Activable Fibrinolysis Inhibitor in Non-Hepatic Cells
Thrombin-activable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like pro-enzyme that, once activated, attenuates fibrinolysis. TAFIa also possesses anti-inflammatory properties. Although liver is the main source ...
Discovery and characterization of an antifreeze protein from Lake Ontario midges
This thesis describes the discovery and characterization of the first antifreeze protein (AFP) isolated from a fly. The starting point of my research was the observation that when midges emerge from Lake Ontario as adults ...
FES Kinase Signaling Promotes Mast Cell Recruitment to Tumours
FES protein-tyrosine kinase (PTK) activation downstream of the KIT receptor in mast cells (MC) promotes cell polarization and migration towards the KIT ligand Stem cell factor (SCF). A variety of tumours secrete SCF to ...
Structural and Functional Characterization of the Human Tribbles Homologue 2 Pseudokinase
The Tribbles Homologues are a family of three eukaryotic pseudokinases (Trb1, Trb2, Trb3) that act as allosteric inhibitors and regulatory scaffold sites in pathways governing adipogenesis, cell proliferation and insulin ...
Investigating the Role of PDE4D1/2 in Vascular Smooth Muscle Cell Desensitization
Vascular smooth muscle cell (VSMC) behaviour and phenotypic modulation is critical to vessel repair following damage, and the progression of various cardiovascular diseases. The second messenger cyclic adenosine monophosphosphate ...