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The Unliganded Glucocorticoid Receptor as a Transcriptional Regulator in Mammary Epithelial Cells
This work presents the first evidence of a ligand-independent role for the glucocorticoid receptor (GR) as a positive regulator of gene expression in mammary cells. We have demonstrated that unliganded GR interacts directly ...
Glucocorticoid Receptor Function and its Role in Tamoxifen Resistance
The function of the glucocorticoid receptor (GR) is crucial for the development and proliferation of normal human breast cells. The primary activity of GR is in its binding to glucocorticoids and the subsequent activation ...
Glucocorticoid Receptor (NR3C1) Promoter Methylation as a Circulating Breast Cancer Biomarker and its Role in Tamoxifen Sensitivity
The glucocorticoid receptor (GR) binds glucocorticoids and transcriptionally regulates genes involved in immune response, cellular proliferation, and apoptosis. Previous work in our lab using MeDIP followed by qPCR found ...
Regulation of the GABPβ Promoter and the Role of NRF-1 in Mammary Epithelial Morphogenesis
Decreased expression of the tumor suppressor gene BRCA1 (breast cancer 1, early onset) is frequently observed in sporadic breast tumors, with the decrease not attributed to mutations or hypermethylation of the promoter. A ...