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Interactions of Lipoprotein(a) with the Plasminogen System: Mechanisms and Pathophysiological Consequences
Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are associated with increased risk of atherothrombotic disease. Lp(a) is a unique lipoprotein consisting of a low density lipoprotein-like moiety covalently linked ...
A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
Previous work has shown that thrombin activatable fibrinolysis inhibitor (TAFI) was unable to prolong lysis of purified clots in the presence of Lys-plasminogen (Lys-Pg), indicating a possible mechanism for fibrinolysis ...
Analysis of Lipoprotein(a) Catabolism
Elevated plasma concentrations of lipoprotein(a) [Lp(a)] have been identified as an independent risk factor for vascular diseases including coronary heart disease and stroke. In the current study, we have examined the ...
Quantitative Investigation into the Mechanisms of Coagulation and Fibrinolysis
Coagulation and fibrinolysis are essential processes that ensure a rapid, localized response to vascular damage and subsequent removal once the damage is repaired. These two processes are extensively regulated by various ...