Department of Pathology and Molecular Medicine Graduate Theses
Recent Submissions
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Characterization of Natural Anti-FVIII Antibodies and the Regulatory Role of the Gut Microbiota in FVIII Immunogenicity
Patients with hemophilia A bleed spontaneously into the soft tissues and joints due to deficiencies in the coagulation protein Factor VIII (FVIII). One-third of patients develop neutralizing antibodies to standard intravenous ... -
Exploring Isoform-specific Roles of Calpain-1 and Calpain-2 in Breast Cancer Metastasis Promoting Cellular Functions
Breast cancer (BC) is the most diagnosed cancer among Canadian women. Among the breast cancer subtypes, triple-negative breast cancer (TNBC) exhibits the poorest survival outcome, likely due to its heterogeneity and lack ... -
The Impact of Respiratory Infection on the Nasal Microbiota
Background: Viral respiratory infections represent a significant burden of illness with high morbidity and mortality, which has been further magnified in recent years by the emergence of Severe Acute Respiratory Syndrome ... -
Dynamics of Clonal Hematopoiesis of Indeterminate Potential and Clinical Outcomes Following Chemotherapy in Lymphoma Patients
Clonal hematopoiesis of indeterminate potential (CHIP) is a potentially premalignant condition of aging that arises upon the expansion of somatically mutated hematopoietic stem/progenitor cells in hematological malignancy-free ... -
High-dimensional Analyses of MicroRNAs in Lung Neuroendocrine Neoplasms
Lung neuroendocrine neoplasms (NENs) are a diverse group of enigmatic cancers. Lung NENs consist of two tumor families: carcinoids, consisting of tumor types typical carcinoids (TC) and atypical carcinoids (AC); and ... -
Development of Bioluminescent Biosensors Monitoring Activity of the Merlin Tumour Suppressor
All solid tumours share the ability to circumvent or overcome contact inhibition of proliferation (CIP), the process by which cell-cell contacts engage signalling to stop proliferation. Merlin, an ERM-like protein, plays ... -
Clinical Utility and Impact of Targeted Nucleic Acid Sequencing in Myeloid Malignancies and Precursor Lesions
Recent technological advances have permitted the identification of several genes recurrently mutated in myeloid malignancies, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN) and acute myeloid ... -
The role of Cadherin/Rac1/gp130/Stat3 in neoplastic transformation mediated by activated Src
Results from Dr. Raptis lab previously demonstrated that engagement of cadherins, cell to cell adhesion molecules (E-, N- cadherin or cadherin-11), triggers a significant increase in levels and activity of the Rac/Cdc42 ... -
Evaluating CD44-EZRIN Interactions in Triple-Negative Breast Cancer: Tumourigenesis and Drug Resistance
When breast cancer is detected at an early localized stage, surgery is often successful in achieving long term survival. However, when breast cancer becomes invasive and progresses to metastatic disease, surgery followed ... -
Downregulation of the unfolded protein response by metformin may confer antineoplastic effects in colorectal cancer
In 2020, there were 1.93 million cases of colorectal cancer (CRC) diagnosed and 935 thousand CRC-related deaths (1–3). Approximately 50 percent of patients are diagnosed with stage III or IV disease, limiting the efficacy ... -
Identification of novel protein tyrosine phosphatases (PTPs) regulating the Hippo pathway in tumorigenesis
The Hippo signaling pathway is a tumor suppressor pathway which plays key roles in normal organ size control through regulation of cell proliferation and cell death. Deregulation of the Hippo pathway leads to excessive ... -
Prognostic Features of Non-Muscle-Invasive Bladder Cancer: Grade, Molecular Subtype and Tumour Immune Microenvironment
Intrinsic molecular subtypes with luminal or basal features have been identified in both breast and bladder cancer as promising areas for biomarker development. These intrinsic molecular subtypes may explain marked variation ... -
Performance of IHC3-Uro Immunohistochemistry-based Molecular Subtyping in Muscle-Invasive Bladder Cancer
Molecular subtyping in muscle-invasive bladder cancer (MIBC) has shown important relationships to both prognosis and chemosensitivity. However, insufficient validation and complex testing methods have prevented molecular ... -
Evaluation of basal and stimulated von Willebrand factor release from endothelial colony forming cells derived from Type 1 von Willebrand disease patients
Type 1 von Willebrand disease (VWD) is the most common bleeding disorder and is thought to be caused by a quantitative deficiency in von Willebrand factor (VWF). Endothelial cells release VWF into the circulation in an ... -
Systematic Identification of Interaction Partners of RET Receptor Isoforms
The REarranged during Transfection (RET) receptor tyrosine kinase is pivotal for normal development of human tissues, but is also an oncogene driver involved in several human cancers. Alternative splicing at the 3’ end ... -
Identification of Novel Small Molecule Inhibitors (SMI) of YAP/TAZ Oncoproteins in Breast Cancer Using HiBiT Bioluminescent Biosensors
Breast cancer (BC) is the most frequently diagnosed cancer among females, accounting for 25% of all cancer cases worldwide. Among all the subtypes of BC, triple negative breast cancer (TNBC) is considered one of the ... -
The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
Background: Clonal hematopoiesis of indeterminate potential (CHIP), a potential precursor to myelodysplastic syndrome (MDS), affects over 10% of adults over 65. Loss-of-function ten-eleven-translocation methylcytosine ... -
The Role of von Willebrand Factor in the Pathogenesis of Deep Vein Thrombosis in Acute Inflammation
Venous thromboembolism, comprised of deep vein thrombosis (DVT) and pulmonary embolism, is a thrombotic cardiovascular disease that accounts for a significant portion of the global health burden. Among its risk factors, ... -
Identification and Characterization of Novel Kinases Regulating Programmed Death Ligand-1 (PD-L1) in Immune Evasion of Triple Negative Breast Cancer Cells
The programmed death ligand-1 (PD-L1) is an immune checkpoint protein expressed on a variety of antigen-presenting cells to normalize immune system. Recently, overexpression of PD-L1 on the surface of cancer cells has been ... -
Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer
Breast cancer is the most frequently diagnosed women’s cancer in Canada. Average patient survival rates are high, but they are significantly reduced for those patients whose cancer reaches stage IV – metastatic disease. ...
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