Browsing Department of Pathology and Molecular Medicine Graduate Theses by Title
Now showing items 112-130 of 130
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Role of the Cadherin-11/Rac1/Stat3 Axis in Src-Mediated Transformation and in Adipocytic Differentiation
Stat3 (signal transducer and activator of transcription-3) is activated by phosphorylation on tyrosine-705 (Stat3-ptyr705) downstream of cytokines, growth factors, and oncogenes. Our lab has demonstrated that engagement ... -
The role of the epithelial-mesenchymal transition in aggressive tumour phenotypes
(2014-10-28)The epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental process characterized by the loss of intercellular contacts, changes in cell polarity and increased migration and invasion. EMT has ... -
The role of the Fer protein-tyrosine kinase in HER2-positive breast cancer
(2015-07-31)Fer is a member of a distinct subclass of cytoplasmic protein-tyrosine kinases with homology to a family of adaptor proteins that regulate membrane-cytoskeletal remodeling events, including receptor endocytosis. Fer has ... -
The Role of von Willebrand Factor in the Pathogenesis of Deep Vein Thrombosis in Acute Inflammation
Venous thromboembolism, comprised of deep vein thrombosis (DVT) and pulmonary embolism, is a thrombotic cardiovascular disease that accounts for a significant portion of the global health burden. Among its risk factors, ... -
The role of von Willebrand factor in the pathogenesis of immunothrombosis
Pathologic immunothrombosis is the formation of arterial, venous or microvascular thrombi in response to dysregulated activation of the immune system. Inflammatory diseases such as sepsis and obesity are associated with a ... -
Roles of the Immune Cytokine Environment on Clonal Growth of Murine and Human Tet2 Mutant Bone Marrow Progenitors: Implications for Myelodysplastic Syndromes
TET2 is a tumor suppressor gene that has been implicated in the epigenetic regulation of gene expression. Inactivating TET2 mutations are common in MDS. These mutations may contribute to early clonal dominance and myeloid ... -
Small Molecule Inhibitors in EGFR/HER-2 and Mutant Ras/Raf Breast Cancer Model Systems
(2013-12-16)Dysregulation of receptor tyrosine kinase (RTK) signaling has been implicated in the pathogenesis of breast cancer. Both EGFR and HER-2 regulate tumor cell proliferation and survival through the Ras-Raf-Mek-Erk (MAPK) ... -
The Src/Stat3 axis in Met signaling in human invasive breast cancer: a potential predictive marker
(2014-01-24)Met has been found to be over-expressed in human breast cancer, correlating with disease progression and poor prognosis. Src and Stat3 have also been found to be over-expressed in many human cancers, including breast. Met, ... -
The Stromal Role of Peroxisome Proliferator-Activated Receptor Gamma in Breast Tumourigenesis
(2014-08-06)Breast cancer is the most commonly diagnosed female cancer, and kills 1 in 30 Canadian women, mostly from metastatic disease. Previous studies showed PPARγ decreases breast cancer progression, but due to the many mammary ... -
Subcellular Localization and Trafficking of the RET Receptor Tyrosine Kinase: Implications for Signalling and Disease
(2012-09-18)The RET proto-oncogene encodes a receptor tyrosine kinase (RTK) that is widely expressed in neuroendocrine tissues and is essential for embryonic development of the kidney and enteric nervous system. Mutations leading to ... -
Systematic Identification of Interaction Partners of RET Receptor Isoforms
The REarranged during Transfection (RET) receptor tyrosine kinase is pivotal for normal development of human tissues, but is also an oncogene driver involved in several human cancers. Alternative splicing at the 3’ end ... -
The Thrombogenic Influences of Factor VIII and von Willebrand Factor
(2015-04-02)von Willebrand factor (VWF) and factor VIII (FVIII) circulate in the blood as a non-covalent complex. VWF plays an important role in primary hemostasis through its interactions with components of the extracellular matrix ... -
Tolerance Induction and The Immunobiology of Factor VIII in Hemophilia A
(2010-09-29)The development of inhibitory antibodies to the factor VIII (FVIII) protein is the greatest complication in the management of hemophilia A patients. These antibodies, which form in approximately 25% of patients, neutralize ... -
Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
(2013-09-03)The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with ... -
Understanding the Hippo-LATS pathway in tumorigenesis
(2011-09-26)The Hippo-LATS signaling pathway originally identified in Drosophila is conserved in mammalian systems and serves essential roles in mediating size control as well as tumorigenesis. In humans, the core kinase cassette ... -
Using Small Molecules to Inhibit an E2A-PBX1:CBP Interaction Involved in Acute Lymphoblastic Leukemia
(2009-09-03)E2A-PBX1 is expressed as a consequence of a recurring chromosomal translocation seen in 5% of acute lymphoblastic leukemia cases. We recently reported that substitution of a leucine residue (L20A) within the N-terminal ... -
Utilizing Caenorhabditis elegans as a novel platform to model human RET receptor function
(2015-02-17)In this study, we report a novel use of Caenorhabditis elegans as a platform to model the function of human RET isoforms, RET9 and RET51. C. elegans does not encompass an orthologue of RET. Thus, we ectopically expressed ... -
Validation of a Gene-Expression Based Assay for BRCA1 Function
(2013-09-26)Breast cancer is a disease that afflicts a significant proportion of women globally. 5-10% of breast cancer cases are linked to inherited polymorphisms in critical genes such as BRCA1, a tumour suppressor essential for ... -
Validation of the Self-BAT (Self-Administered Bleeding Assessment Tool) and Evaluation of Determinants of Health in Hemophilia Carriers
(2015-11-18)Hemophilia A and B are X-linked deficiencies of coagulation factor VIII and IX respectively. Males are affected, while females are carriers of the disease. Recently, it has become clear that more than a third of hemophilia ...