Browsing Department of Pathology and Molecular Medicine Graduate Theses by Title
Now showing items 44-63 of 120
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Generation and Optimization of the Self-Administered Bleeding Assessment Tool
(2013-05-02)Defects in haemostasis, specifically in the quantitative or qualitative properties of von Willebrand factor (VWF), result in the most commonly inherited bleeding disorder, von Willebrand disease (VWD). Of the three types ... -
Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
(2010-10-19)Retinoblastoma is the second most common childhood intraocular malignancy and development of the tumour is initiated by bi-allelic loss of the RB1 gene. Bi-allelic RB1 loss may not always directly lead to malignant ... -
Identification and characterization of E2A-PBX1 genomic binding sites using ChIP-seq and bioinformatics
(2014-07-16)A translocation between chromosomes 1 and 19, referred to as t(1;19), results in expression of the chimeric, oncogenic transcription factor E2A-PBX1 in cases of B-progenitor acute lymphoblastic leukemia. Previous studies ... -
Identification and characterization of transcriptional targets of TAZ in human breast cancer
TAZ is a transcriptional co-activator and an effector of the Hippo signaling pathway. Since its discovery in 2000, we have gained tremendous insights into the roles TAZ plays in development and disease. TAZ acts as an ... -
Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
(2014-08-25)The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ... -
The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
(2009-04-14)An estimated 5-10% of breast cancers are hereditary in nature and are due to the presence of a mutation in a breast cancer predisposition gene; approximately half of these cases possess a mutation in BRCA1 or BRCA2. Many ... -
Identification of Novel Proteins Interacting with LATS1/2 During Tumorigenesis and Anti-Tubulin Drug Response
The Hippo pathway is a signaling cascade that plays essential roles in organisms such as development, organ size control, stem cell differentiation and renewal, as well as important processes necessary for cancer development ... -
Identification of Novel Receptor Tyrosine Kinases Regulating the Hippo Pathway in Cancer Cells
Several studies have shown that the Hippo pathway plays an important role in tissue growth, organ size control, and cell death. Deregulation of the Hippo pathway contributes to loss of cell contact inhibition and continuing ... -
Identifying a Prognostic Test in Follicular Lymphoma Using a Tissue Microarray and Immunohistochemistry
(2008-07-08)Follicular lymphoma (FL) is an attractive model for discovering biomarkers and elucidating mechanisms of tumour progression. We hypothesized that alterations in the expression of proteins with known roles in cancer biology ... -
Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
(2014-09-17)The transcriptional co-activator with PDZ-binding domain (TAZ) is a transcriptional co-activator and downstream component of the tumor suppressor Hippo pathway that plays critical roles in organ size control, stem cell ... -
An immune modulatory role for the fes proto-oncogene
(2015-07-21)The Fes protein tyrosine kinase is abundantly expressed in phagocytic immune cells, including tumor associated macrophages. Fes knockout mice (fes-/-) display enhanced sensitivity to LPS, and this was shown to be associated ... -
Impact of Androgen Deprivation Therapy on the Gastrointestinal Microbiota of Prostate Cancer Patients
Background: Prostate Cancer (PCa) is one of the leading causes of cancer in men. Androgen deprivation therapy (ADT), the standard of care for advanced PCa, has been associated with developing the metabolic syndrome. The ... -
In Vitro Characterization of the Function of ABCA1: Effects of Naturally Occurring Mutations
(2010-02-12)The ATP-binding cassette (ABC) transporter, ABCA1, plays a pivotal role in reverse cholesterol transport, which is the elimination of excess sterols from peripheral cells and their transport to the liver for elimination. ... -
The Influence of Sequence Variation on von Willebrand Factor Biosynthesis, Proteolytic Processing and Clearance
(2012-08-07)Von Willebrand factor (VWF) promotes platelet adhesion and aggregation at sites of vascular damage. This function is directly related to the multimer size of VWF. The VWF-specific metalloprotease ADAMTS13 decreases VWF ... -
Integrating Phospholipid and Cyclic Nucleotide Signaling: Roles of Phosphodiesterases as Enzymes and Tethers
(2011-06-28)Cells of the cardiovascular system translate incoming extracellular signals from hormones and drugs through binding of cell surface receptors, and activation of intracellular signaling cascades allowing modulation of ... -
Investigating the Genetic Basis of Type 3 of Von Willebrand Disease (VWD)
(2013-10-18)von Willebrand Disease (VWD) is the most common inherited bleeding disorder in humans, resulting from quantitative or qualitative deficiencies of von Willebrand factor (VWF). Type 3 VWD is the rarest and most severe form ... -
Investigating the relationship between the RET receptor, Cbl and ARHGEF7 in downregulation of RET
(2008-07-15)The RET proto-oncogene encodes a receptor tyrosine kinase (RTK), with two major isoforms, RET9 and RET51, which differ in their C-termini, and therefore recruit different signaling complexes. RET plays an important role ... -
Investigating the Role of cAMP-Signaling in the Regulation of Vascular Endothelial Cell Adaptive Responses to Fluid Shear Stress
(2016-05-11)The circulating blood exerts a force on the vascular endothelium, termed fluid shear stress (FSS), which directly impacts numerous vascular endothelial cell (VEC) functions. For example, high rates of linear and undisturbed ... -
Investigating the role of PDE4D7 in vascular smooth muscle cell migration
(2015-08-31)Inhibiting the maladaptive migration of vascular smooth muscle cells (VSMCs) in injured blood vessels can help to reduce the development of intimal lesions in vascular diseases such as atherosclerosis and restenosis. Cyclic ...