Browsing Department of Pathology and Molecular Medicine Graduate Theses by Title
Now showing items 67-86 of 119
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Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer
(2016-08-31)Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management ... -
The Mammary Epithelial Cell-Specific Role of Peroxisome Proliferator-Activated Receptor (PPAR)γ in DMBA-Mediated Breast Tumourigenesis
(2008-09-04)Breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths, among women world-wide. Improved understanding of breast tumourigenesis may facilitate the development of more ... -
The Mammary Epithelial Contribution Of PPARγ In Breast Tumourigenesis
(2014-08-06)Previous studies with peroxisome proliferator-activated receptor (PPAR)γ heterozygous mice suggest PPARγ normally suppresses 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast tumour progression, but the mechanisms and ... -
Mapping and Antagonizing the Interaction Between Phosphodiesterase 3B and Exchange Protein Activated by cAMP-1 Elucidates Their Roles in Endothelial Cell Adhesion
(2009-10-07)The ubiquitous second messenger cAMP acts to integrate and translate information encoded by extracellular messenger molecules, including hormones and neurotransmitters. Intracellular cAMP concentrations are regulated through ... -
Metabolic features of prostate malignancy
Altered metabolism is an inherent property of cancer and provides a rich opportunity for exploring its underlying biology and developing diagnostic biomarkers. We used desorption electrospray ionization mass spectrometry ... -
MicroRNA-193B Functions as a Tumor Suppressor in Malignant Melanoma
(2012-05-31)Cutaneous melanoma is an increasingly common skin cancer characterized by aggressive metastatic growth and poor prognosis. The mechanisms behind melanoma progression are not fully understood, but emerging evidence suggests ... -
MicroRNA-205 Involvement in Cutaneous Melanoma
(2012-07-09)Cutaneous melanoma is an increasingly common aggressive malignancy. The molecular mechanisms responsible for melanoma’s initiation and progression are still unclear, but new evidence suggests microRNAs (miRNAs) may be ... -
Modulation of Human Multidrug Resistance Proteins by Reactive Quinone-based Glutathione Conjugates
(2015-02-17)The multidrug resistance protein 1 (MRP1) and MRP2 mediate the ATP-dependent cellular efflux of a diverse set of organic molecules including many glutathione (GSH) conjugates. In the present study, a series of GSH conjugated ... -
Molecular Characterization of Gleason Patterns 3 and 4 Prostate Cancer Using Reverse Warburg Effect-Associated Genes
(2015-11-16)Background: Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, GP ... -
Molecular Characterization of Human Homologs of Yeast MOB
(2008-09-24)MOB (Mps One Binder) is a conserved gene family found in all major kingdoms. The MOB genes are essential components acting in mitotic exit and cytokinesis in both budding and fission yeasts. They are further identified as ... -
The molecular mechanism of TAZ-induced mammary tumorigenesis
(2013-08-02)TAZ (Transcriptional co-activator with PDZ-binding motif) is a WW-domain containing protein recently identified as a downstream component of the Hippo tumor suppressor pathway and mediator of biologically important processes ... -
Molecular Stress Signaling in Breast Epithelial Cells
(2008-01-15)Breast cancer is a complex disease, whose etiology is not well understood. A number of factors have been found to contribute to its development. Psychological stress has been recognized as such a factor in epidemiological ... -
Novel mechanisms of Stat3 activation
(2010-02-23)Stat3 (signal transducer and activator of transcription-3) is activated by a number of receptor and non-receptor tyrosine kinases, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic ... -
Novel Methods of Factor VIII Tolerance Induction in Hemophilia A Mouse Models
The most serious complication of factor VIII (FVIII) replacement therapy in hemophilia A (HA) patients remains the development of anti-FVIII antibodies (inhibitors). At this time, there are no methods to prevent inhibitor ... -
A Novel Regulatory Role of Ezrin in Promoting Breast Cancer Cell Invasion and Metastasis
(2015-04-23)Metastasis is the leading cause of death for breast cancer patients and poses significant clinical challenges in the successful treatment of breast cancer. The cytoskeleton crosslinker protein ezrin, is frequently ... -
THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
(2012-09-11)Evidence indicates that the mammary epithelium is arranged in a hierarchy in which mature luminal and myoepithelial cells are derived from stem cells through a series of lineage-restricted intermediates. One of the more ... -
Protein Kinase A, Exchange Protein Activated By cAMP 1, and Phosphodiesterase 4D All Associate With VE-Cadherin to Regulate Endothelial Barrier Function
(2007-09-17)Vascular endothelial cells (VECs) play an essential role in regulating the passage of macromolecules and cells between the blood stream and underlying tissues. The second messenger 3’, 5’ cyclic adenosine monophosphate ... -
RAD9A Stabilization and Destabilization Processes in Checkpoint Maintenance and Checkpoint Recovery
(2015-11-30)The phosphorylation of the sensor-checkpoint Rad9A is essential for Chk1 activation in S-phase and during the G2/M checkpoints. Previous studies have demonstrated a late phosphorylation of Rad9A after DNA damage. Rad9A ... -
Recurrent Copy Number Alterations in Prostate Cancer: the Genomic Impact of PTEN Deletions and the Prostate-Specific ETS Gene Fusions
(2014-04-29)Prostate cancer is a clinically heterogeneous disease, with manifestations ranging from a rapid and often fatal progression, to indolent disease. Unfortunately, current clinicopathological criteria cannot differentiate men ... -
The regions connecting the membrane spanning and nucleotide binding domains of MRP1 are functionally distinct
Multidrug resistance protein 1 (MRP1) is a 190 kDa ATP-binding cassette transporter which effluxes xeno- and endobiotic organic anions including estradiol glucuronide (E217βG) and the pro-inflammatory leukotriene C4 (LTC4). ...