Browsing Department of Pathology and Molecular Medicine Graduate Theses by Title
Now showing items 92-111 of 130
-
RAD9A Stabilization and Destabilization Processes in Checkpoint Maintenance and Checkpoint Recovery
(2015-11-30)The phosphorylation of the sensor-checkpoint Rad9A is essential for Chk1 activation in S-phase and during the G2/M checkpoints. Previous studies have demonstrated a late phosphorylation of Rad9A after DNA damage. Rad9A ... -
Recurrent Copy Number Alterations in Prostate Cancer: the Genomic Impact of PTEN Deletions and the Prostate-Specific ETS Gene Fusions
(2014-04-29)Prostate cancer is a clinically heterogeneous disease, with manifestations ranging from a rapid and often fatal progression, to indolent disease. Unfortunately, current clinicopathological criteria cannot differentiate men ... -
The regions connecting the membrane spanning and nucleotide binding domains of MRP1 are functionally distinct
Multidrug resistance protein 1 (MRP1) is a 190 kDa ATP-binding cassette transporter which effluxes xeno- and endobiotic organic anions including estradiol glucuronide (E217βG) and the pro-inflammatory leukotriene C4 (LTC4). ... -
Regulation of HC11 Mouse Mammary Epithelial Cell Differentiation by the Rac/Stat3 axis
Studying cellular differentiation can reveal valuable information underlying the mechanisms that mediate cell fate. The HC11 mouse mammary epithelial cell line has long been used as a model to study lactogenic differentiation ... -
Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Most breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status ... -
RET Mediated Gene Expression and Cell-Migration
(2011-11-08)The RET receptor tyrosine kinase is important during development of neural crest-derived tissues, particularly the enteric and sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex ... -
RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
(2015-01-20)The RET receptor has diverse roles in development and disease, modulating proliferation, survival, and migration of cells. Ligand-independent constitutively active forms of RET can lead to thyroid neoplasia. Missense ... -
The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
(2010-06-07)The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation. Oncogenic activation of RET causes the cancer syndrome multiple endocrine neoplasia type 2 (MEN 2), and is a frequent ... -
A Role for Fer in Prostate and Breast Cancer
(2009-11-18)Phosphorylation of substrates by kinase proteins is one of the most prominent mechanisms by which signal transduction occurs and dysregulation of this activity is implicated as a major underlying cause of a number of ... -
The Role of ALDH1A3 in Normal and Transformed Mammary Gland Development
(2012-09-27)Aldehyde dehydrogenases (ALDHs) have been used as stem cell markers in a variety of tissues, including the breast. However, it is currently unknown whether ALDH family members participate in normal mammary development or ... -
Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
(2015-12-16)Osteosarcoma is an aggressive bone malignancy with neither reliable prognostic or predictive biomarkers nor drugs for targeted therapy. It is the most common malignant tumour of bone, predominantly occurring in adolescents. ... -
The Role of BetaPIX in RET-mediated Cell Migration
(2009-09-23)RET is a transmembrane receptor that is implicated in a variety of processes such as cell proliferation, differentiation, migration, survival, and death. One of the proteins that is activated downstream of RET is the guanine ... -
The Role of Cadherin-11 and gp130 in Transformation by Activated Src
(2011-11-29)Signal Transducer and Activator of Transcription 3, Stat3, has been associated with cytokine-induced proliferation, anti-apoptosis and neoplastic transformation, while constitutively active Stat3 has been found in many ... -
Role of Cell Adhesion Microenvironment and the Src/Stat3 Axis in Autocrine HGF Signaling During Breast Tumourigenesis
(2008-09-22)Over-expression of both hepatocyte growth factor (HGF) and its receptor Met frequently occurs in invasive human breast cancer, suggesting that the establishment of an HGF “autocrine loop” may be linked to breast tumour ... -
The Role of Compartmented cAMP Signalling in the Regulation of Vascular Endothelial Cell Permeability
(2009-09-22)Vascular endothelial cells (VECs) maintain vascular integrity by regulating the passage of solutes, macromolecules, and cells between the vascular and perivascular space and are critical in a wide number of physiological ... -
The role of extracellular vesicles in the transfer of multidrug resistance in human ovarian cancer cells
Ovarian cancer is the fifth most common cancer in Canadian women and has the highest mortality rate of all gynecologic malignancies. First-line treatment is typically cytoreductive surgery followed by a combination of ... -
The role of PPARg-dependent microRNA expression during breast tumour metastasis
Previous studies by Dr. Nicol showed the first direct in vivo evidence that peroxisome proliferator-activated receptor (PPAR)γ normally suppresses environmental chemical 7,12-dimethylbenz[a]anthracene (DMBA)-mediated breast ... -
The Role of Stat3 in Adipocytic Differentiation
(2014-09-27)Cellular proliferation is often regulated in conjunction with differentiation. It is important to investigate the mechanisms underlying cellular differentiation and proliferation, because defects in their control can ... -
The role of Stat3 in cell division and apoptosis
(2009-04-27)The Signal Transducer and Activator of Transcription-3 (Stat3) is a transcription factor that is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to ... -
The Role of TET2 in Macrophage Differentiation and Polarization
The epigenetic regulator Tet methylcytosine dioxygenase 2 (TET2) catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), leading to DNA demethylation. Inactivating TET2 mutations are common ...