Browsing Department of Pathology and Molecular Medicine Graduate Theses by Subject "Cancer"
Now showing items 1-9 of 9
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Application of Cysteine Scanning Mutagenesis to the Multidrug Resistance Protein (MRP)1
(2009-02-17)Multidrug resistance protein (MRP)1, a member of the ABCC branch of the ATP-binding cassette (ABC) superfamily of transporters, can confer resistance to a broad spectrum of chemotherapeutic agents. In addition to the core ... -
Characterization of isoform specific RET knockdown in cancer cell lines
(2013-08-30)The REarranged in Transfection (RET) tyrosine kinase is an important signalling protein for the development of neural crest-derived tissues such as the enteric and sympathetic nervous systems. RET is constitutively activated ... -
Characterizing the Role of the RET Receptor Tyrosine Kinase in Colorectal Cancer
RET is a receptor tyrosine kinase (RTK) that plays important roles in both normal development and cancer. RET has well-established oncogenic roles in thyroid cancer and growing evidence implicates RET activity in the ... -
Differential Contributions of RET-isoforms to Tumour Invasion
RET is a receptor tyrosine kinase (RTK) which is normally activated at the cell surface by glial cell line-derived neurotrophic factors and plays critical roles during embryogenesis. RET is expressed as two protein isoforms, ... -
Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
(2014-08-25)The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ... -
Identification of Novel Proteins Interacting with LATS1/2 During Tumorigenesis and Anti-Tubulin Drug Response
The Hippo pathway is a signaling cascade that plays essential roles in organisms such as development, organ size control, stem cell differentiation and renewal, as well as important processes necessary for cancer development ... -
Identification of Novel Receptor Tyrosine Kinases Regulating the Hippo Pathway in Cancer Cells
Several studies have shown that the Hippo pathway plays an important role in tissue growth, organ size control, and cell death. Deregulation of the Hippo pathway contributes to loss of cell contact inhibition and continuing ... -
RET Mediated Gene Expression and Cell-Migration
(2011-11-08)The RET receptor tyrosine kinase is important during development of neural crest-derived tissues, particularly the enteric and sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex ... -
A Role for Fer in Prostate and Breast Cancer
(2009-11-18)Phosphorylation of substrates by kinase proteins is one of the most prominent mechanisms by which signal transduction occurs and dysregulation of this activity is implicated as a major underlying cause of a number of ...