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    • Browsing Department of Pathology and Molecular Medicine Graduate Theses by Subject
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    • Department of Pathology and Molecular Medicine Graduate Theses
    • Browsing Department of Pathology and Molecular Medicine Graduate Theses by Subject
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    Browsing Department of Pathology and Molecular Medicine Graduate Theses by Subject "YAP"

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      • Exploring the regulation of YAP and TAZ in antitubulin drug response and mammary tumorigenesis 

        Zhao, Yulei (2015-12-22)
        TAZ and YAP are transcriptional coactivators negatively regulated in the tumor suppressor (TS) Hippo pathway. TAZ and YAP play essential roles in tumorigenesis, epithelial mesenchymal transition (EMT) as well as cell ...
      • Identification and characterization of transcriptional targets of TAZ in human breast cancer 

        van Rensburg, Ellen
        TAZ is a transcriptional co-activator and an effector of the Hippo signaling pathway. Since its discovery in 2000, we have gained tremendous insights into the roles TAZ plays in development and disease. TAZ acts as an ...
      • Identification of Novel Receptor Tyrosine Kinases Regulating the Hippo Pathway in Cancer Cells 

        Azad, Taha
        Several studies have shown that the Hippo pathway plays an important role in tissue growth, organ size control, and cell death. Deregulation of the Hippo pathway contributes to loss of cell contact inhibition and continuing ...
      • Identification of Novel Small Molecule Inhibitors (SMI) of YAP/TAZ Oncoproteins in Breast Cancer Using HiBiT Bioluminescent Biosensors 

        Wu, Liqing
        Breast cancer (BC) is the most frequently diagnosed cancer among females, accounting for 25% of all cancer cases worldwide. Among all the subtypes of BC, triple negative breast cancer (TNBC) is considered one of the ...

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