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Biotransformation and DNA Repair in 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Pulmonary Carcinogenesis
Studies described in this thesis were at aimed at characterizing the mechanisms involved in the pulmonary carcinogenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by ...
INVESTIGATION OF THE BIOTRANSFORMATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE BY PROSTAGLANDIN H SYNTHASE AND CYTOCHROME P450 2F
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is believed to play a role in human lung cancer induced by tobacco smoking. NNK biotransformation may involve the enzymes prostaglandin ...
DNA oxidation and base excision repair in lung and liver of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone treated mice
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen found in unburned tobacco and tobacco smoke. To exert its carcinogenic effect, NNK is metabolically activated to reactive intermediates ...