Now showing items 1-5 of 5
Characterization of NfxB and PA4596, Two Repressors of the mexCD-oprJ Operon Encoding an RND-Type Multidrug Efflux Pump in Pseudomonas aeruginosa
MexCD-OprJ is an RND-type multidrug efflux pump present in P. aeruginosa and is capable of exporting, and as such providing resistance to, several clinically important antimicrobials including fluoroquinolones, cephems, ...
Characterization of the Alphaherpesvirus Tegument Protein US2
Members of the Herpesviridae are large enveloped, double-stranded DNA viruses, whose virions are comprised of a viral genome-containing icosahedral capsid, a layer of tegument and a glycoprotein-embedded envelope. The ...
NEU1 SIALIDASE AND MATRIX METALLOPROTEINASE-9 CROSS-TALK IS ESSENTIAL FOR TOLL-LIKE RECEPTOR ACTIVATION AND CELLULAR SIGNALING
The molecular mechanism(s) by which Toll-like receptors become activated are not well understood. For the majority of TLR receptors, dimerization is a prerequisite to facilitate MyD88-TLR complex formation and subsequent ...
Novel Functions of IL-27 in Innate Immunity: Characterization of IL-27-induced Inflammatory Responses in Human Monocytes and Impact of HIV Infection on IL-27 Expression and Function
Interleukins, cytokines secreted by leukocytes, are predominant messengers modulating immune responses. Interleukin-27 (IL-27), a key immunomodulatory cytokine, functions to induce both pro- and anti-inflammatory effects ...
PA5471 modulation of the Pseudomonas aeruginosa mexXY multidrug efflux pump operon repressor MexZ: Identification of important interaction residues and domains
Chemotherapeutic treatment of Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is substantially challenged by several membrane-spanning, multidrug-efflux pumps of the three-component RND family. Of these ...