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The Influence of 1,25-Dihydroxyvitamin D3 on the Cross-Priming of Lymphocytic Choriomeningitis Virus Nucleoprotein
Biologically active 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) binds the vitamin D receptor (VDR) to exert its effect on target cells. VDR expression is found in a number of immune cells including professional antigen-presenting ...
IDENTIFICATION OF NOVEL GENES INVOLVED IN N-GLYCOSYLATION AND REGULATION OF ARCHAELLA ASSEMBLY AND EXPLORATION OF THE EFFECT OF N-GLYCOSYLATION ON ARCHAELLA ASSEMBLY IN METHANOCOCCUS MARIPALUDIS
In this thesis, using Methanococcus maripaludis as a model organism, significant, novel advances have been made to the understanding of the archaeal N-glycosylation pathway as well as archaella regulation and assembly. The ...
ROLE OF MULTIPLE TOLL-LIKE RECEPTOR ACTIVATION IN REGULATING CYTOTOXIC T CELL PRIMING TO LYMPOCYTIC CHORIOMENINGITIS VIRUS INFECTIONS
Foreign pathogens are recognized by toll-like receptors (TLR), present on various immune cells such as professional antigen-presenting cells (pAPCs). On recognition of its ligand, these receptors activate pAPCs, which may ...
Impact of RNA Viruses on the Regulation of IL-23 in Mouse and Human Models of Infection
Interluekin-23 (IL-23) is a pro-inflammatory cytokine critical to the regulation of innate and adaptive immune responses. The main role for this cytokine is in the proliferation and differentiation of the IL-17 producing ...