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The Role of Neu1 Sialidase in Epidermal Growth Factor Receptor Activation
The epidermal growth factor receptor (EGFR) exists as a single, highly glycosylated subunit receptor on the plasma membrane of a cell. Upon ligand binding to its extracellular domain, the EGFR dimerizes with an adjacent ...
THE ROLE OF NEU1 SIALIDASE IN Trk TYROSINE KINASE RECEPTOR ACTIVATION
The signaling pathways of tyrosine kinase Trk receptors and their downstream biological effects are well known, but the parameters controlling the interactions between the receptors and their natural ligands still remain ...
Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
Thymoquinone (TQ), a volatile oil component of black seed oil (derived from Nigella sativa), has been shown to have various biological effects including disease treatment and prevention. TQ is believed to share similar ...