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dc.contributor.authorZara, Lian C.en
dc.date2014-02-26 22:24:32.243
dc.date.accessioned2014-03-03T18:17:17Z
dc.date.issued2014-03-03
dc.identifier.urihttp://hdl.handle.net/1974/8645
dc.descriptionThesis (Master, Biology) -- Queen's University, 2014-02-26 22:24:32.243en
dc.description.abstractSleep is an evolutionary conserved behaviour which in most species is essential for survival. However, the mechanisms involved in the genetic regulation of sleep remain poorly understood. C. elegans exhibit a number of sleep-like behaviours: a) lethargus which is a developmental period between moults, b) satiety which occurs after feeding and c) after long durations of thrashing in liquid media. We have isolated a C. elegans G-protein coupled receptor, named NPR-14,that is most similar to the human orexin receptor 2 and is involved in the above behaviours and functions through a protein kinase G - dependent and independent pathways. NPR-14 works together with other signalling pathways that have been implicated in sleep regulation including Notch, GABA, and insulin signalling. A null mutation in npr-14 results in anachronistic quiescence especially in the presence of food. It also results in egg-laying defects, episodic swimming behaviour, asynchronicity during development and despite feeding less these mutants appear to accumulate more fat than N2 worms.en
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectGPCRen
dc.subjectGeneticsen
dc.titleA G-protein coupled receptor is involved in the regulation of sleep and metabolismen
dc.typethesisen
dc.description.restricted-thesisNot sure when data is going to be published.en
dc.description.degreeM.Sc.en
dc.contributor.supervisorBendena, William G.en
dc.contributor.departmentBiologyen
dc.embargo.terms1825en
dc.embargo.liftdate2019-03-02
dc.degree.grantorQueen's University at Kingstonen


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