How Generalizable are Randomized Controlled trials (RCTs) in Staphylococcus aureus Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies

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Date
2022-03-04
Authors
Bai, Anthony
Lo, Carson K. L.
Komorowski, Adam
Suresh, Mallika
Guo, Kevin
Garg, Akhil
Tandon, Pranav
Senecal, Julien
Del Corpo, Olivier
Stefanova, Isabella
Keyword
Staphylococcus aureus , Bacteremia , Mortality , Trials
Abstract
In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lower treatment effect when applying RCT results to bedside care.