Muscle Contraction Force Conforms to Muscle Oxygenation during Constant Activation Voluntary Forearm Exercise

dc.contributor.authorDrouin, Patrick
dc.contributor.authorForbes, Stacey
dc.contributor.authorLiu, Taylor
dc.contributor.authorLew, Lindsay
dc.contributor.authorMcGarity-Shipley, Ellen
dc.contributor.authorTschakovsky, Michael
dc.date.accessioned2022-08-29T15:06:42Z
dc.date.available2022-08-29T15:06:42Z
dc.date.issued2022-08-16
dc.descriptionThis is the peer reviewed version of the following article: Drouin, P. J., Forbes, S. P. A., Liu, T., Lew, L. A., McGarity-Shipley, E., & Tschakovsky, M. E. (2022). Muscle contraction force conforms to muscle oxygenation during constant activation voluntary forearm exercise. Experimental Physiology, which has been published in final form at https://doi.org/10.1113/EP090576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.en
dc.description.abstractIn electrically stimulated skeletal muscle, force production is downregulated when oxygen delivery is compromised and rapidly restored upon oxygen delivery restoration in the absence of cellular disturbance. Whether this “oxygen conforming” response of force occurs and is exercise intensity dependent during stable voluntary muscle activation in humans is unknown. In 12-participants (6-female), handgrip force, forearm muscle activation (electromyography; EMG), muscle oxygenation, and forearm blood flow (FBF) were measured during rhythmic handgrip exercise at forearm EMG achieving 50, 75 or 90% critical impulse (CI). 4-min of brachial artery compression to reduce FBF by ∼60% (Hypoperfusion) or sham compression (adjacent to artery; Control) was performed during exercise. Sham compression had no effect. Hypoperfusion rapidly reduced muscle oxygenation at all exercise intensities, resulting in contraction force per muscle activation (force/EMG) progressively declining over 4 min by ∼16% in 75 and 90% CI. No force/EMG decline occurred in 50% CI. Rapid restoration of muscle oxygenation post-compression was closely followed by force/EMG such that it was not different from Control within 30-sec for 90% CI and after 90-sec for 75% CI. Our findings reveal an oxygen conforming response does occur in voluntary exercising muscle in humans. Within the exercise modality and magnitude of fluctuation of oxygenation in this study, the oxygen conforming response appears to be exercise intensity dependent. Mechanisms responsible for this oxygen conforming response have implications for exercise tolerance and warrant investigation.en
dc.identifier.citationDrouin, P. J., Forbes, S. P. A., Liu, T., Lew, L. A., McGarity-Shipley, E., & Tschakovsky, M. E. (2022). Muscle contraction force conforms to muscle oxygenation during constant activation voluntary forearm exercise. Experimental Physiology, https://doi.org/10.1113/EP090576en
dc.identifier.doihttps://doi.org/10.1113/EP090576
dc.identifier.urihttp://hdl.handle.net/1974/30324
dc.language.isoenen
dc.publisherWileyen
dc.relationDiscovery Granten
dc.relationResearch Tools and Instruments Granten
dc.relationAlexander Graham Bell CGS Doctoral Scholarshipen
dc.subjectExerciseen
dc.subjectOxygen deliveryen
dc.subjectSkeletal muscleen
dc.titleMuscle Contraction Force Conforms to Muscle Oxygenation during Constant Activation Voluntary Forearm Exerciseen
dc.typejournal articleen
oaire.awardNumberRGPIN/05078-2016en
oaire.awardNumberEQPEQ0407690-11en
project.funder.identifierhttp://dx.doi.org/10.13039/501100000038en
project.funder.identifierhttp://dx.doi.org/10.13039/501100000038en
project.funder.identifierhttp://dx.doi.org/10.13039/501100000038en
project.funder.identifierhttp://dx.doi.org/10.13039/501100000196en
project.funder.identifierhttp://dx.doi.org/10.13039/100008185en
project.funder.nameNatural Sciences and Engineering Research Council of Canadaen
project.funder.nameNatural Sciences and Engineering Research Council of Canadaen
project.funder.nameNatural Sciences and Engineering Research Council of Canadaen
project.funder.nameCanadian Foundation for Innovationen
project.funder.nameOntario Innovation Trusten
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