The experimental investigation of the micro-vibrations underlying Temporal Enhanced ultrasound

dc.contributor.authorLi, Si Jiaen
dc.contributor.departmentComputingen
dc.contributor.supervisorMousavi, Parvinen
dc.contributor.supervisorLoock, Hans-Peteren
dc.date.accessioned2018-09-13T19:58:24Z
dc.date.available2018-09-13T19:58:24Z
dc.degree.grantorQueen's University at Kingstonen
dc.description.abstractTemporal enhanced Ultrasound (TeUS) is a non-invasive imaging approach, recently proposed by our group. TeUS makes use of ultrasound time series for tissue classification, and it has been successfully applied to ex vivo prostate tissue classification, breast cancer detection, and prostate cancer grading. Of particular importance is the physical phenomenon underlying the tissue characterizing capability of TeUS. Our group previously proposed that physiological micro-vibrations are a source of tissue differentiation. These micro-vibrations are induced by blood perfusion (heart beat: ~ 1 Hz) and breathing (0.2-0.4 Hz). Our group then derived a theory that integrates the effect of micro-vibrations into the standard imaging equation. We validated this theory by digitally simulating micro-vibrations in benign and cancerous pathology and demonstrated that response to the micro-vibrations can be the basis for differentiating the tissues. This thesis aims to find experimental evidence to support the theory. Specifically, I accurately simulated and measured micro-vibrations; I then studied the mechanical properties of the tissue and their relationship to TeUS, through tissue mimicking phantom studies. First, I adapted a fiber optic sensor for micro-vibration detection. The sensor was shown to be capable of simultaneously capturing low frequency micro-vibration as well as megahertz ultrasound transmission waveforms. The sensor is expected to be an invaluable tool for studying micro-vibrations and developing advanced ultrasound tissue characterization technologies. I then developed and characterized tissue mimicking phantoms with an integrated micro-vibration mechanism. To investigate the effects of micro-vibrations on TeUS, I built the tissue mimicking phantoms that differed in ultrasound scatterer size and elasticity. I collected TeUS signals and showed that TeUS is sensitive to scatterer size and elasticity through micro-vibrations. These results provided experimental evidence to the hypothesis that physiological micro-vibrations are a cause of TeUS differentiation, as proposed by our group's previous work. They also warrant the translation of TeUS to other types of material characterization tasks.en
dc.description.degreeM.Sc.en
dc.identifier.urihttp://hdl.handle.net/1974/24832
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canadaen
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreementen
dc.rightsIntellectual Property Guidelines at Queen's Universityen
dc.rightsCopying and Preserving Your Thesisen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectTemporal Enhanced Ultrasounden
dc.subjecttissue characterizationen
dc.subjectfiber-optic sensingen
dc.subjectmicro-vibrationsen
dc.titleThe experimental investigation of the micro-vibrations underlying Temporal Enhanced ultrasounden
dc.typethesisen
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