The Effects of Microbial Ecosystem Therapeutic-2 on Sleep Disturbances in Individuals with Major Depressive Disorder
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Authors
Bromley, Hayley
Date
Type
thesis
Language
eng
Keyword
Depression , Major depressive disorder , Sleep , Sleep disturbance , Microbiome , Gut-brain axis
Alternative Title
Abstract
Objective: The primary objective of this thesis is to evaluate the effects of microbial ecosystem therapeutic-2 (MET-2) in comparison to a placebo on sleep disturbances in individuals with major depressive disorder (MDD) during a 6-week treatment period, with follow-up assessments at 12- and 24-weeks post-treatment. The secondary objectives are to assess changes in mood at the same intervals and to assess any correlations between sleep and mood.
Methods: Data from this thesis were derived from the METDA study, a phase 2 double-blind placebo-controlled trial that recruited individuals with MDD in the Kingston and Toronto areas. Participants were randomly assigned to receive either MET-2 or a placebo for 6 weeks. Longitudinal effects of MET-2 were explored in a follow-up sub-study at 12- and 24-weeks post-treatment. The Pittsburgh Sleep Quality Index (PSQI) and the Montgomery Åsberg Depression Rating Scale (MADRS) evaluated changes in sleep and mood, respectively, at each time point.
Results: Among the 27 participants included in the analysis of this thesis, a two-way repeated measures ANOVA showed significant improvements in PSQI scores within the MET-2 group (n= 13) compared to the placebo group (n= 14) from baseline to week 6 (p= 0.044) and baseline to week 18 (p= 0.011), after adjusting for sex and age. Although MADRS scores did not display inter-group differences, intra-group trends revealed notable mood improvements in MET-2 recipients from baseline to week 6 (p<0.001) and baseline to week 12 (p= 0.003).
Conclusion: This study is the first to examine the potential efficacy of MET-2 in mitigating sleep disturbances in individuals with MDD, suggesting the potential benefits in treating sleep-related symptoms in MDD. The results of this study contribute to a growing body of research on gut repopulation as a treatment method for a variety of psychiatric illnesses, offering new insights and directions for future investigations.
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Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada
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This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution-NonCommercial-NoDerivatives 4.0 International
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution-NonCommercial-NoDerivatives 4.0 International