Melatonin Patterns Among Female Hospital Employees On Day And Night Shifts: Assessment By Different Exposure Metrics
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Authors
Leung, Michael
Date
2015-09-17
Type
thesis
Language
eng
Keyword
Melatonin , rhythm , cosinor , Light , Cancer , mesor , amplitude , Shiftwork , acrophase , DAG , Chronic disease , circadian
Alternative Title
Abstract
Objective:
To assess the associations of different shift work exposure metrics with circadian melatonin mesor, amplitude and acrophase.
Methods:
In a cross-sectional study of 328 female hospital personnel working fixed-day or rotation schedules, shift work exposure metrics were determined through self-report. 6-sulfatoxymelatonin concentrations were analyzed by cosinor analysis.
Results:
Shift workers working at night had lower mesors and earlier acrophases than day workers. Shift workers working three or more consecutive nights had lower mesors and smaller amplitudes than those working less than three consecutive nights. After adjusting for confounders, acrophases were no longer different, while smaller amplitudes were apparent among shift workers compared to day workers. Shift length or duration of shift work were not associated with melatonin pattern.
Conclusion:
Rotating patterns of shift work, specifically high intensity rotations, are associated with depressed melatonin rhythms, an indicator of circadian disruption.
Description
Thesis (Master, Community Health & Epidemiology) -- Queen's University, 2015-09-16 20:48:10.031
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Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada
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Creative Commons - Attribution - CC BY
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
Creative Commons - Attribution - CC BY
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.