Polymer micelles for the protection and delivery of specialized pro-resolving meditators
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Authors
de Prinse, Mitchell
Date
Type
thesis
Language
eng
Keyword
specialized pro-resolving mediators , polymer biomaterials , micelles , in vitro release
Alternative Title
Abstract
Specialized pro-resolving mediators (SPM) play a pivotal role in the resolution of acute inflammation events and have recently gained interest as a treatment for chronic inflammation. Polymer micelles are a promising approach for the delivery of these SPMs as they can protect them from oxidative degradation as well as improve their bioavailability. In this study block copolymers of poly(ethylene glycol) and poly(trimethylene carbonate-5-benzyloxy-trimethylene carbonate) (P(TMC-BTMC)) were produced via ring-opening polymerization. The BTMC units were also modified with sorbic acid in an attempt to introduce additional interactions between the micelle core and the model drug linoleic acid. The block copolymers created formed stable micelles capable of high loading of linoleic acid. In vitro release of linoleic acid was observed over 4 weeks and showed no signs of a burst phase. The polymer micelles also reduced the extent of oxidation of linoleic acid prior to its release compared to a linoleic acid control.
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Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada
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Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
CC0 1.0 Universal
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
CC0 1.0 Universal