Polymer micelles for the protection and delivery of specialized pro-resolving meditators

dc.contributor.authorde Prinse, Mitchellen
dc.contributor.departmentChemical Engineeringen
dc.contributor.supervisorAmsden, Brian
dc.date.accessioned2021-03-18T19:00:15Z
dc.date.available2021-03-18T19:00:15Z
dc.degree.grantorQueen's University at Kingstonen
dc.description.abstractSpecialized pro-resolving mediators (SPM) play a pivotal role in the resolution of acute inflammation events and have recently gained interest as a treatment for chronic inflammation. Polymer micelles are a promising approach for the delivery of these SPMs as they can protect them from oxidative degradation as well as improve their bioavailability. In this study block copolymers of poly(ethylene glycol) and poly(trimethylene carbonate-5-benzyloxy-trimethylene carbonate) (P(TMC-BTMC)) were produced via ring-opening polymerization. The BTMC units were also modified with sorbic acid in an attempt to introduce additional interactions between the micelle core and the model drug linoleic acid. The block copolymers created formed stable micelles capable of high loading of linoleic acid. In vitro release of linoleic acid was observed over 4 weeks and showed no signs of a burst phase. The polymer micelles also reduced the extent of oxidation of linoleic acid prior to its release compared to a linoleic acid control.en
dc.description.degreeM.A.Sc.en
dc.identifier.urihttp://hdl.handle.net/1974/28727
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada*
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreement*
dc.rightsIntellectual Property Guidelines at Queen's University*
dc.rightsCopying and Preserving Your Thesis*
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.*
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectspecialized pro-resolving mediatorsen
dc.subjectpolymer biomaterialsen
dc.subjectmicellesen
dc.subjectin vitro releaseen
dc.titlePolymer micelles for the protection and delivery of specialized pro-resolving meditatorsen
dc.typethesisen
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