Non-Invasive IntraOcular Pressure Monitoring with Contact Lens

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Lai, Yong Jun
Campigotto, Angelica
Leahy, Stephane
Zhao, Guowei
Campbell, Robert
Glaucoma , Contact Lens , Intraocular Pressure , Micro-fluidics
Background: Glaucoma is the second leading cause of blindness in the world and the first leading cause of irreversible vision loss. Currently the primary methodology of testing for the intraocular pressure (IOP) is during clinical office hours, which only provide a limited amount of information on the trends and fluctuations of the IOP. Therefore, a continuous monitoring system is required to properly determine the peaks of pressure and to negate any false results obtained by sparse, clinic hour testing. The objective of this study is to determine the ability of a newly designed contact lens with an embedded microchannel, to accurately measure the fluctuations in the IOP. Methods: Experimentation was completed on fresh enucleated porcine eyes. The contact lens was placed on the porcine eye and utilizing a camera the fluid movement, within the microchannel in the contact lens, was recorded. A micro pressure catheter threaded into the center of the vitreous chamber, recorded the true intraocular pressure and was compared to the displacement of the indicator fluid within the microchannel. Results: The contact lenses showed a consistent linear responsiveness to changes in IOP and robust to the effects of anatomic differences among eyes. The indicator fluid had an average fluid movement of 28 um/mmHg between all the trials. Additionally, the devices showed the ability to measure both increases and decreases in IOP during cyclical fluctuations. Conclusion: The described inexpensive and non-invasive sensor is able to reliably monitor the IOP changes based on porcine eye model.
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