Update on long QT syndrome
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Authors
Neira, Victor
Enriquez, Andrés
Simpson, Chris
Baranchuk, Adrian
Date
2019
Type
preprint
Language
en
Keyword
Electrocardiography , Long QT , QT Interval , Torsades de Pointes
Alternative Title
Abstract
Long QT syndrome (LQTS) is an inherited disorder characterized by a prolonged QT interval in the 12‐lead electrocardiogram and increased risk of malignant arrhythmias in patients with a structurally normal heart. Since its first description in the 1950s, advances in molecular genetics have greatly improved our understanding of the cause and mechanisms of this disease. Sixteen genes linked to LQTS have been described and genetic testing had become an integral part of the diagnosis and risk stratification. This article provides an updated review of the genetic basis, diagnosis, and clinical management of LQTS.
Description
Citation
Publisher
Wiley
License
This is the peer reviewed version of the following article: Neira, Victor, Enriquez, Andrés, Simpson, Chris, Baranchuk, Adrian, Update on Long QT Syndrome, Journal of Cardiovascular Electrophysiology, which has been published in final form at https://doi.org/10.1111/jce.14227. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.