The Effects of Sprint Interval Training on Circulating TNF-α and IL-6 Independent of Changes in Abdominal Adipocyte Size in Overweight Adults

dc.contributor.authorMatusiak, Jenniferen
dc.contributor.departmentKinesiology and Health Studiesen
dc.contributor.supervisorGurd, Brendon J.en
dc.date.accessioned2017-03-20T18:10:05Z
dc.date.available2017-03-20T18:10:05Z
dc.degree.grantorQueen's University at Kingstonen
dc.description.abstractAdipose tissue is actively involved in both the inflammatory response associated with obesity and in the determination of whole body substrate selection. In humans, evidence suggests that exercise improves adipose tissue function by reducing adipocyte inflammation; however, the mechanisms by which this occurs are not fully understood. It has been suggested that exercise may improve adipose tissue function by reducing adipose cell size. It remains unknown whether exercise influences adipose tissue function independent of reductions in adipocyte size. Elevated levels of circulating TNF-α and IL-6 are both associated with adipose tissue dysfunction and insulin resistance. The purpose of this study was to examine whether four weeks of sprint-interval training (SIT) was an effective means of reducing elevated circulating TNF-α and IL-6 independent of altering abdominal adipose cell size in men. 8 overweight healthy men (age: 25.13 years, weight; 113.5kg). Methods: VO2peak (L/min), adipocyte size, serum IL-6 and serum TNF-α were measured before and after 16 sessions of sprint interval training over four weeks. Results: The key findings of this experiment included that exercise significantly reduces circulating TNF-α (p=0.03) and IL-6 (p=0.05) independent of changes in weight, waist circumference and abdominal adipocyte size in overweight men. VO2 peak also significantly (p=0.04) improved after the four-week protocol. These results confirm that exercise can improve adipose tissue function independent of weight loss or changes in abdominal adipocyte size.en
dc.description.degreeM.Sc.en
dc.identifier.urihttp://hdl.handle.net/1974/15456
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsCC0 1.0 Universalen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canadaen
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreementen
dc.rightsIntellectual Property Guidelines at Queen's Universityen
dc.rightsCopying and Preserving Your Thesisen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectSprint Interval Trainingen
dc.subjectCirculating TNF-α and IL-6en
dc.subjectAdiposeen
dc.subjectAbdominal Adipocyte sizeen
dc.titleThe Effects of Sprint Interval Training on Circulating TNF-α and IL-6 Independent of Changes in Abdominal Adipocyte Size in Overweight Adultsen
dc.typethesisen
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