Investigating the role of Neuropeptide Y infusions to the dorsal hippocampus in mediating behaviour in several animal models of anxiety

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O'Dunn-Orto, Charelle
Neuropeptide Y , Dorsal hippocampus , rats , anxiety
Both Neuropeptide Y (NPY) and the dorsal hippocampus have consistently been found to regulate anxiety-related behaviours in both humans and animals. However, although the dorsal hippocampus contains a high concentration of NPY receptors very little research has examined the effect of NPY infusions into the dorsal hippocampus on anxiety-like behaviours. The current study tested the hypothesis that acute injection of NPY into the dorsal hippocampus decreases anxiety-like behaviours. To test this hypothesis, bilateral infusion of 1.5 ug/side of NPY (n = 7) or sterile water vehicle (n = 8) into the rat dorsal hippocampus was followed by behavioural testing in three animal models of anxiety: i.e., the elevated plus-maze, novelty-induced suppression of feeding and shock-probe burying test. NPY-treated rats displayed no significant differences in behaviour in all three animal models of anxiety. Although the results of the current study did not support the hypothesis that NPY injection will reduce anxiety-like behaviours, a thorough review of the literature provides ample support for further investigation in this area.
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