Steroids and antidepressant response
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Authors
Baldessarini, Ross J.
Vázquez, Gustavo H.
Date
2019-05-24
Type
journal article
Language
Keyword
Alternative Title
Abstract
The recent meta-analytic review of trials involving anti-inflammatory agents to treat or to supplement treatment of patients with major depressive disorder (MDD) or depressive symptoms by Köhler-Forsberg and colleagues [1] includes data derived from 36 controlled trials. Treatments included glucocorticoids as well as cytokine inhibitors, minocycline, nonsteroidal anti-inflammatory drugs (NSAIDs), pioglitazone, and statins. There were 14 randomized, controlled trials involving addition of one of these agents versus placebo to standard antidepressants to treat acute episodes of MDD in 597 subjects. The resulting data analyzed by random-effects meta-analysis yielded a highly significant standardized mean drug-placebo difference (SMD) of –0.64 (95% CI: –0.88 to –0.40; z=5.17, p<0.00001) in which 9/14 trials (64.3%) individually yielded statistically significant differences, with moderate heterogeneity (I2 = 51%). This article is protected by copyright. All rights reserved.
Description
This is the peer reviewed version of the following article: Baldessarini, R. J., & Vázquez, G. H. (2019). Steroids and antidepressant response. Acta Psychiatrica Scandinavica. doi:10.1111/acps.13056, which has been published in final form at http://dx.doi.org/10.1111/acps.13056. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Citation
Baldessarini, R. J., & Vázquez, G. H. (2019). Steroids and antidepressant response. Acta Psychiatrica Scandinavica. doi:10.1111/acps.13056
Publisher
Wiley