On certain two-signal perspectives of lymphocyte activation and inactivation, thymic G-quadruplexes, and the role of aggregation in self/not-self discrimination
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Authors
Forsdyke, Donald R.
Date
2019-06-05
Type
journal article
Language
Keyword
autoimmunity , cell activation , immunodeficiency , infections , MHC , repertoire development , T cell receptors , thymus , tolerance/suppression/anergy
Alternative Title
Abstract
Distinctive “two signal” paths in immunology, taken by researchers with different academic backgrounds, seem to have both contained facets of the truth. Having been influenced by education at a medical school where Almroth Wright’s early contributions were not forgotten, the author’s “path less followed” led to views that began to gain recognition late in the twentieth century when the intimate relationship between innate and acquired immunity became more apparent.
Description
This is the peer reviewed version of the following article: Forsdyke, D. R. (2019). On certain two‐signal perspectives of lymphocyte activation and inactivation, thymic G‐quadruplexes, and the role of aggregation in self/not‐self discrimination. Scandinavian Journal of Immunology, e12797. doi:10.1111/sji.12797, which has been published in final form at http://dx.doi.org/10.1111/sji.12797. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Citation
Forsdyke, D. R. (2019). On certain two‐signal perspectives of lymphocyte activation and inactivation, thymic G‐quadruplexes, and the role of aggregation in self/not‐self discrimination. Scandinavian Journal of Immunology, e12797. doi:10.1111/sji.12797
Publisher
Wiley