Examining the Association Between Change in Non-exercise Estimated Cardiorespiratory Fitness and Mortality in Men
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Authors
Houle, Sarah
Date
Type
thesis
Language
eng
Keyword
cardiorespiratory fitness , mortality , cardiovascular disease
Alternative Title
Abstract
Cardiorespiratory fitness (CRF) is a strong, independent predictor of morbidity and mortality. The addition of CRF to cardiovascular disease (CVD) risk prediction algorithms enhances individual risk stratification. However, CRF is not routinely measured in health care settings as exercise testing is neither feasible nor appropriate to perform during most patient encounters.
Non-exercise estimated CRF has been suggested as a pragmatic alternative to exercise testing. While initial evidence suggests that estimated CRF is an independent predictor of mortality beyond age, biological sex, race, and traditional CVD risk factors, these findings are based on prospective cohort studies that use a single baseline measure of CRF. Consequently, these studies may be subject to exposure misclassification and residual confounding. By examining the change in estimated CRF over time, these issues can be mitigated. Therefore, the purpose of this thesis was to investigate whether change in estimated CRF is associated with CVD and all-cause mortality risk.
We examined data from 10445 men who participated in the Aerobics Center Longitudinal Study between 1979 and 2002. Participants completed two comprehensive medical examinations and were then followed for mortality or until December 31st, 2003. Change in estimated CRF was derived using the Jackson et al. (2012) and Nes et al. (2011) algorithms.
Our findings suggest that the association between change in estimated CRF and mortality is equation dependent. Whereas change in estimated CRF using the Jackson equation was independently associated with CVD and all-cause mortality, change in estimated CRF using the Nes equation was not associated with mortality. Nevertheless, implementation of estimated CRF assessment in health care settings provides an opportunity for practitioners to counsel patients on the importance of physical activity and provides a metric to assess treatment efficacy.
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This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution-NonCommercial-NoDerivs 3.0 United States
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution-NonCommercial-NoDerivs 3.0 United States