A Multi-Advisor Evaluation Module for the Accurate Prediction of Alpha Helix Pairs
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Authors
Sedfawi, Steve Joseph
Date
2007-09-17T18:06:00Z
Type
thesis
Language
eng
Keyword
protein structure , protein , proteomics , contact maps , helix-pairs , FORR
Alternative Title
Abstract
Accurate 3D protein structure prediction is one of the most challenging problems
facing bioinformaticians today. This thesis develops and examines an evaluation module
for ranking predicted super-secondary structures – specifically a-helix pairs – as part of a
case-based reasoning system.
The proposed module is part of the Triptych project, which aims at the accurate
prediction of the three-dimensional structure of proteins from contact maps. Triptych is
an advanced case-based reasoning system that utilizes a library of existing protein
structures and motifs to help predict the structure of a known polypeptide chain of amino
acids that represents a target a-helix pair.
The proposed module evaluates possible solutions by integrating multiple
strategies, learning methods and sources of knowledge in the form of expert advisors. It
uses advisors which integrate knowledge from the fields of biology, biochemistry,
classical physics, and statistical data analysis obtained from pre-determined structures.
Lastly, the proposed evaluation module would allow for the integration of more
sources of knowledge, in the form of expert advisors, as well as serve as a framework for
evaluating other structural motifs in future.
Description
Thesis (Master, Computing) -- Queen's University, 2007-09-09 19:42:59.094
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