Synthesis of Ni(dppe)2 and Nickel (I) Catalysts and their Ability to Catalyzed Cross-Coupling
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Authors
Alfahd, Anfal
Date
2016-04-27
Type
thesis
Language
eng
Keyword
synthesis of nickel complexes , Nickel cross-coupling
Alternative Title
Abstract
Nickel catalysts play a growing role in effecting a variety of cross-coupling reactions in which carbon-carbon bonds are formed. Nickel compounds have several advantages over more frequently used palladium analogues, including the ability to activate aliphatic electrophiles and to avoid β-hydrogen elimination by alkyl-metal intermediates. Both Ni(II) and Ni(0) precursors are commonly utilized, with the latter oxidation state often believed to function as the catalytically active species. In recent years, however, a number of Ni(I) compounds have also been reported to behave as apparent catalysts and, since Ni(0) and Ni(I) compounds may be readily interconvertible, it is not always clear which oxidation state forms the actual catalyst in any particular cross-coupling reaction. Ni(0) was synthesised using a zinc reduction and analyzed by NMR spectroscopy. Ni(I) was produced using comproportionation reaction and analyzed with elemental analysis. This thesis describes an investigation in which we compare Ni(0), Ni(I) and Ni(II) complexes containing phosphine and halide (Cl-, Br-, I-) ligands , in this case 1,2-bis(diphenylphosphino)ethane (dppe) for their abilities to effect e.g. Buchwald-Hartwig Amination, Heck-Mizoroki and Suzuki-Miyaura reactions with different types of substrates.
Description
Thesis (Master, Chemistry) -- Queen's University, 2016-04-27 13:04:24.876
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ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
Creative Commons - Attribution - CC BY
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.