Balancing Cardiac Activation and Peripheral Vasodilation: Determinants of Cardiovascular Circuit Flow During Leg Exercise
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Authors
Zedic, Abigail
Date
2025-01-30
Type
thesis
Language
eng
Keyword
Cardiac Output , Vasodilation , Leg Blood Flow , Dynamic Exercise , Cardiovascular Control
Alternative Title
Abstract
The extent to which central mechanisms can independently increase cardiovascular circuit blood flow (CBF) during exercise is not well defined. Studies using atrial pacing during exercise to evoke a proportionally greater cardiac activation response observe no increases in CBF but fail to replicate exercise-induced cardiac activation. Therefore, we investigated whether excess exercise-induced cardiac activation was able to independently drive CBF at exercise onset. To isolate the contribution of exercise-induced cardiac activation of CBF, 30 participants performed knee extension/flexion exercise at 50% WRPEAK during two conditions. 1) CON: right leg exercise, with left leg blood flow occlusion (pneumatic cuff; 280 mmHg); 2) ECA: dual leg exercise, with left leg blood flow occlusion to increase cardiac activation above single leg exercise, without additional vasculature participating in CBF. Central and peripheral hemodynamics were measured continuously. Heart rate and cardiac output were higher in ECA compared to CON during the first 30 seconds of exercise, while stroke volume remained unchanged between conditions. Mean arterial pressure was also higher in ECA, primarily due to the increased cardiac output as there were greater increases in total vascular conductance during ECA. Leg blood flow was greater in ECA compared to CON, but this increase was not due to a greater leg vascular conductance. Instead, leg blood flow appears to be driven by a pressor- mediated response caused by the higher cardiac output in ECA. These results demonstrate that excess exercise-induced cardiac activation can increase the CO and exercising leg perfusion response within the first 30 seconds of sub-maximal knee extension/flexion exercise onset.
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Attribution-NonCommercial-NoDerivatives 4.0 International
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution-NonCommercial-NoDerivatives 4.0 International