LncRNAs are Differentially Expressed in Skeletal Muscle Following Acute Aerobic and Resistance Exercise: A Bioinformatics Analysis
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Authors
Regnier, Kassia
Date
Type
thesis
Language
eng
Keyword
lncRNAs , bioinformatics , exercise physiology , RNA-seq , biochemistry , molecular biology
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Abstract
Although there has been a great deal of research on the molecular mechanisms that regulate responses to different modes of acute exercise in human skeletal muscle, there is still much to be discovered. Advances in high-throughput sequencing technologies, such as RNA sequencing (RNA-seq), have immense potential in furthering our understanding of exercise biology. Increasing evidence suggests that long non-coding RNAs (lncRNAs) have regulatory functions in many biological processes, including the adaptive response to exercise. Here, I analyzed the expression of lncRNAs in skeletal muscle following acute aerobic exercise (AE) and resistance exercise (RE). I downloaded publicly available RNA-seq data (skeletal muscle biopsies from Dickinson et al., 2018) to conduct a bioinformatics analysis to investigate the expression of lncRNAs following different types of exercise (AE vs. RE). To characterize the expression patterns of lncRNAs following different types of acute exercise, I performed a differential expression analysis and compared lncRNA expression profiles between different exercise types (AE vs. RE) at three time points (baseline, 1-hour post-exercise, 4 hours post-exercise). For the first time, I report distinct lncRNA profiles between acute AE and RE at different time points. Together, these results suggest that lncRNAs may have different roles in the regulation of the response to different types of acute exercise in skeletal muscle. These findings emphasize the unique transcriptomic response of skeletal muscle to different modes of acute exercise and warrant future studies on the roles of lncRNAs in the response to acute exercise in skeletal muscle.
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Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada
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Attribution-NonCommercial-NoDerivs 3.0 United States
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution-NonCommercial-NoDerivs 3.0 United States