Reconfigurations of Cortico-Subcortical Manifold Structure During Reward-Based Motor Learning
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Authors
Niksefat, M Qasem
Date
Type
thesis
Language
eng
Keyword
Motor learning , reward-based learning , neural manifold , brain connectivity , motor control
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Abstract
In this thesis, we explore the complex interplay between higher-order brain systems and the sensorimotor cortex during the process of learning, specifically within the context of adaptive motor behavior. Employing functional Magnetic Resonance Imaging (MRI), we monitor human brain activity as participants carry out a task which requires them to adjust their hand movements based on reinforcement feedback. Our methodology includes mapping patterns of cortical and subcortical functional connectivity onto a low-dimensional mathematical space, referred to as a manifold, and tracking how regions within this space expand and contract throughout the learning process.
Our findings present a novel pattern of connectivity shifts between sensorimotor areas and other critical brain networks at distinct stages of learning. During the early learning phase, we observe increased covariance between sensorimotor areas in the Dorsal Attention Network (DAN) and the salience/ventral attention network, coupled with a decrease in covariance with regions of the Default Mode Network (DMN). This pattern undergoes a reversal during the later stages of learning, with increased covariance noted between sensorimotor areas and DMN regions, and decreased connectivity with salience/ventral attention network areas.
Furthermore, we establish a correlation between the individual performance of participants and the expansion and contraction patterns of the Dorsal Attention Network regions within the manifold space. These observations provide a unique perspective on the neural foundations of reward-based motor learning and how the changes in functional coupling between the medial prefrontal cortex and sensorimotor cortex accompany different learning stages.
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Queen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canada
ProQuest PhD and Master's Theses International Dissemination Agreement
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Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution 3.0 United States
ProQuest PhD and Master's Theses International Dissemination Agreement
Intellectual Property Guidelines at Queen's University
Copying and Preserving Your Thesis
This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.
Attribution 3.0 United States