Effect of Glycogen Synthase Kinase-3 Inhibition on the Acquisition and Expression of Cocaine-Cue Conditioned Activity and Spontaneous Locomotion in Rodents

dc.contributor.authorRocca, Jeffery Francescoen
dc.contributor.departmentPsychologyen
dc.contributor.supervisorBeninger, Richard J.en
dc.date2014-10-08 13:55:28.116
dc.date.accessioned2014-10-09T19:22:33Z
dc.date.issued2014-10-09
dc.degree.grantorQueen's University at Kingstonen
dc.descriptionThesis (Master, Psychology) -- Queen's University, 2014-10-08 13:55:28.116en
dc.description.abstractPairing environmental stimuli with pro-dopaminergic drugs can produce conditioned effects on locomotor behaviour in rodents, an effect that is used to model incentive learning and drug craving in laboratory animals. One of the targets of dopamine signaling is glycogen synthase kinase-3 (GSK-3), a nearly constitutively active enzyme involved in a variety of cellular activities and signaling pathways. Recently, GSK-3 has been shown to be modulated by activity at the dopamine D2 and D3 receptors, both of which have been implicated in the acquisition and expression of conditioned activity. Here, it was hypothesized that the selective GSK-3 inhibitor, A-1070722 (Abbott Laboratories, Ludwigshafen, Germany), would block the acquisition and expression of cocaine-cue conditioned activity in Wistar rats. Results indicated a block of the expression, but not acquisition, of conditioned activity at 10 and 20 mg/kg doses of A-1070722, but not 0, 1, or 5 mg/kg doses. The 10 mg/kg dose also appeared to decrease spontaneous locomotion, suggesting that the effect of A-1070722 on the expression of conditioned activity may be due an effect on locomotor behaviour more generally, rather than being due to a selective attenuation of the expression of incentive learning produced by cocaine-associated environmental stimuli.en
dc.description.degreeM.Sc.en
dc.description.restricted-thesisOne of the compounds used in this project (A-1070722) is protected by its producer, Abbott Laboratories, and permission is needed to publish any work related to it.en
dc.embargo.liftdate2019-10-08
dc.embargo.terms1825en
dc.identifier.urihttp://hdl.handle.net/1974/12576
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectDopamineen
dc.subjectGSK-3en
dc.subjectCocaineen
dc.subjectIncentive Learningen
dc.subjectConditioned Activityen
dc.titleEffect of Glycogen Synthase Kinase-3 Inhibition on the Acquisition and Expression of Cocaine-Cue Conditioned Activity and Spontaneous Locomotion in Rodentsen
dc.typethesisen
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