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    Browsing by Author "D'Souza, Yohan"

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      • Investigating Organic Nitrate Tolerance and Alzheimer's Disease: Roles for Aldehyde Dehydrogenase 2 and 4-Hydroxynonenal 

        D'Souza, Yohan (2013-06-04)
        Organic nitrates, such as glyceryl trinitrate (GTN), have been used clinically for more than a century. However optimal nitrate therapy is hindered by the development of tolerance, which is associated with a desensitized ...
      • The Role of Aldehyde Dehydrogenase 2 in Nitrate Tolerance 

        D'Souza, Yohan (2008-10-21)
        Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat myocardial ischemia and congestive heart failure. GTN is proposed to act as a prodrug that requires bioactivation for pharmacological activity. ...

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