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dc.contributor.authorO'Dunn-Orto, Charelleen
dc.date2014-10-21 14:14:03.576
dc.date.accessioned2014-10-21T18:30:19Z
dc.date.available2014-10-21T18:30:19Z
dc.date.issued2014-10-21
dc.identifier.urihttp://hdl.handle.net/1974/12591
dc.descriptionThesis (Master, Psychology) -- Queen's University, 2014-10-21 14:14:03.576en
dc.description.abstractBoth Neuropeptide Y (NPY) and the dorsal hippocampus have consistently been found to regulate anxiety-related behaviours in both humans and animals. However, although the dorsal hippocampus contains a high concentration of NPY receptors very little research has examined the effect of NPY infusions into the dorsal hippocampus on anxiety-like behaviours. The current study tested the hypothesis that acute injection of NPY into the dorsal hippocampus decreases anxiety-like behaviours. To test this hypothesis, bilateral infusion of 1.5 ug/side of NPY (n = 7) or sterile water vehicle (n = 8) into the rat dorsal hippocampus was followed by behavioural testing in three animal models of anxiety: i.e., the elevated plus-maze, novelty-induced suppression of feeding and shock-probe burying test. NPY-treated rats displayed no significant differences in behaviour in all three animal models of anxiety. Although the results of the current study did not support the hypothesis that NPY injection will reduce anxiety-like behaviours, a thorough review of the literature provides ample support for further investigation in this area.en
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectNeuropeptide Yen
dc.subjectDorsal hippocampusen
dc.subjectratsen
dc.subjectanxietyen
dc.titleInvestigating the role of Neuropeptide Y infusions to the dorsal hippocampus in mediating behaviour in several animal models of anxietyen
dc.typethesisen
dc.description.degreeM.Sc.en
dc.contributor.supervisorMenard, Janet L.en
dc.contributor.departmentPsychologyen
dc.degree.grantorQueen's University at Kingstonen


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