Biomedical and Molecular Sciences, Department of
The Department of Biomedical and Molecular Sciences strives to provide students with the best conditions to develop into independent, productive, research scientists in a dynamic learning environment.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
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Anatomical Sciences Graduate Projects
This collection contains Pattern II MSc in Anatomical Sciences graduate projects
Recent Submissions
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Investigating the Interplay Between Endothelial BMPR2 Loss, Interleukin-15 Signaling, and Sex Hormones in the Pathogenesis of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a disease of occlusive vascular remodeling, resulting in increased resistance in the lungs vasculature, progressive decrease in cardiac output, and eventually death from right heart ... -
A Peripartum Assessment of Nailfold Capillary Density in Women With Preeclampsia
Preeclampsia (PE) is characterized as new-onset hypertension in pregnancy (>140mmHg systolic or >90mmHg diastolic), along with proteinuria and is a leading cause of maternal mortality and morbidity worldwide. Despite the ... -
A Role for the HSV Tegument Protein pUL21 in Retention of Viral Genomes Within Capsids
Herpes simplex virus (HSV) virions are comprised of a double-stranded DNA genome packaged at high pressure within an icosahedral capsid, surrounded by tegument proteins and a lipid envelope studded with viral glycoproteins. ... -
Investigating the Role of Trained Immunity in Bacillus Calmette-Guérin Immunotherapy of Bladder Cancer Using a Mouse Model
The gold-standard treatment for non-muscle invasive bladder cancer (NMIBC) is adjuvant intravesical Bacillus Calmette-Guérin (BCG) immunotherapy following transurethral resection of bladder tumour (TURBT). BCG is a ... -
Functional MRI Investigation of the Neural Basis of Human Pain Processing in the Brainstem and Spinal Cord; Descending Regulation and Chronic Pain
Pain is a complex experience that includes sensory components, descending pain modulation, and cognitive and emotional effects. A combination of any or all of these effects may be altered in chronic pain conditions. The ... -
The Role of the IL-17 and IL-33 Axis in the Pathophysiology of Endometriosis
Endometriosis is a gynecological condition characterized by the growth of endometrial tissue outside of the uterine cavity. The widely accepted theory of pathogenesis, Sampson’s theory of retrograde menstruation, postulates ... -
The intersection of pain, disease severity, and circadian disruption in experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an autoimmune disease causing neuroinflammation and demyelination to the central nervous system. The overall goal of this thesis was to explore an emerging area of research in the MS field: ... -
Biosynthesis of the Pseudomonas aeruginosa Common Polysaccharide Antigen by D-Rhamnosyltransferases WbpX and WbpY
The Gram-negative bacterium Pseudomonas aeruginosa is responsible for chronic and antibiotic-resistant infection in cystic fibrosis patients and immunocompromised individuals and is one of the leading organisms associated ... -
Delineating the Roles of Kinesin and Dynein Motor Proteins During Mitotic Spindle Assembly and Function in the Fungal Pathogen Candida albicans
During cell division, cells must accurately orchestrate and execute DNA segregation to daughter cells. To do this, eukaryotes assemble a dynamic macromolecular structure called the mitotic spindle, which undergoes a series ... -
Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
Benzene is a known human leukemogen and environmental pollutant. Recent epidemiological evidence has shown that benzene exposure during pregnancy is associated with increased infant leukemias after birth. It is hypothesized ... -
Exploration of the Mechanism of Action of Human Oviduct-Specific Glycoprotein (OVGP1) in Regulating Sperm Capacitation
The present research is of significance to the field of fertility treatment as better understanding the mechanism that regulates the function of oviduct-specific glycoprotein (OVGP1) could lead to its supplementation to ... -
Deletion, Mutation, and Biochemical Analyses of the Ice Nucleation Protein from Pseudomonas borealis
Outer membrane-associated ice nucleation proteins (INPs) in certain Gram-negative bacteria can cause frost damage to plants by nucleating ice in supercooled water. The INP central domain consists of ~55-80 tandem sixteen-residue ... -
Hydrogen Peroxide and Phosphoinositide Metabolites Synergistically Regulate a Cation Current to Influence Neuroendocrine Cell Bursting
(Wiley, 2021-10-22)In various neurons, including neuroendocrine cells, non-selective cation channels elicit plateau potentials and persistent firing. Reproduction in the marine snail, Aplysia californica, is initiated when the neuroendocrine ... -
Hydrogen peroxide regulates a cation channel to control neuroendocrine cell excitability
Non-selective cation channels promote neuronal spiking in many animals. For the hermaphroditic marine snail, Aplysia californica, synaptic input to neuroendocrine bag cell neurons triggers various cation channels, causing ... -
Broad-spectrum inhibitor of bacterial polyphosphate homeostasis attenuates virulence factors and helps reveal novel physiology of K. pneumoniae and A. baumannii
Acinetobacter baumannii and Klebsiella pneumoniae currently rank amongst the most antibiotic-resistant pathogens, responsible for numerous infections each year. In the wake of this continuing crisis, anti-virulence ... -
Nutrient and Stress-Induced Mitochondrial Hyperfusion Regulates Cell Death Pathways
Mitochondria undergo constant cycles of remodelling to sustain normal cell function. As the major cellular metabolic hub, mitochondria are understood to require a precise balance of membrane fission and fusion to maintain ... -
Characterizing the Impact of Dietary Mineral Intake on Secondary Hyperparathyroidism, Vascular Calcification, and Bone Disease Within Experimental Chronic Kidney Disease
Chronic kidney disease (CKD) affects an estimated 25 million North Americans and is a significant risk factor for cardiovascular disease (CVD) and overall mortality. This is largely a result of systemic dysregulation in ... -
Evaluation of the Environmental Exposure Unit as an Appropriate Model to Study House Dust Mite-Induced Allergic Rhinitis
Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa. Upon allergen exposure, such as to house dust mite (HDM), IL-33 is among mediators released by damaged epithelial cells, initiating a Th2-mediated ... -
Investigating Sexual Dimorphism in Murine Bladders and Plasmacytoid Dendritic Cell Response to BCG and STING Pathway Activation
The incidence of urothelial carcinoma of the bladder (UCB) is four times higher in males than females; however, females tend to present with a more aggressive disease, a poorer response to immunotherapy, and suffer worse ... -
Circadian Rhythmicity of Chronic Low Back Pain: A Cross-Sectional Study
Chronic low back pain (CLBP) is defined as pain occurring between the ribcage and buttocks, maladaptively persisting for longer than 3 months. Unfortunately, current treatments are often associated with several negative ...
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