Biomedical and Molecular Sciences, Department of
The Department of Biomedical and Molecular Sciences strives to provide students with the best conditions to develop into independent, productive, research scientists in a dynamic learning environment.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
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Anatomical Sciences Graduate Projects
This collection contains Pattern II MSc in Anatomical Sciences graduate projects
Recent Submissions
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How Fusarium graminearum GPCRs Contribute To Fungal Virulence On Wheat
Fusarium graminearum is the principal causal agent of Fusarium Head Blight, one of the most destructive diseases of wheat. Infection of wheat by F. graminearum results in contamination of the grains with harmful mycotoxins ... -
Structure-Activity Relationships in Adhesins from Environmental Bacteria
The aggregation of bacteria into the form of biofilms is a measure of their success in colonizing biotic and abiotic surfaces. Biofilm communities provide the sheltering bacteria with resistance against biocides like ... -
Vibrio cholerae's Largest Adhesin and How to Block It
Numerous species of pathogenic Gram-negative bacteria produce repeats-in-toxin adhesins to bind to host cells and subsequently form biofilms during a bacterial infection. These long, membrane-anchored proteins typically ... -
Modulation of Electrical Transmission in Aplysia Bag Cell Neurons by cAMP Through a Postsynaptic Mechanism
Direct electrical communication between neurons occurs via electrical coupling, which is achieved through paired hemi-channels known as gap junctions. These inter-cellular channels promote synchronized, rapid, and reliable ... -
Investigating the Effects of In Utero Benzene Exposure on Murine Fetal Placenta DNA Repair Gene Expression
Benzene is a ubiquitous pollutant found in the environment, in car emissions, cigarette smoke, and at elevated levels in the industrial manufacturing of plastics, resins and dyes. Exposure to benzene results in carcinogenic ... -
Examining the structure and role of the C-terminal tail domain of a motile microtubule-depolymerizing kinesin
Kinesins are a family of force-generating enzymes that transport cellular cargos along microtubule trackways and restructure the mitotic spindle to segregate chromosomes. Members of the kinesin-8 family possess the dual ... -
Tracing The Origin Of A Lectin-like Antifreeze Protein
Type II antifreeze proteins (AFPs) are C-type lectin homologs found in three lineages of teleost fish (Cottidae, Clupeiformes and Osmeriformes). Previous work demonstrated that the AFP gene was horizontally transferred ... -
Protein Engineering of Antifreeze Proteins Reveals that Their Activity Scales with the Area of the Ice-Binding Site
(Wiley, 2022-12-02)Antifreeze proteins (AFPs) protect organisms from freezing by binding to ice crystals to prevent their growth. Here, we have investigated how the area of an AFP's ice-binding site (IBS) changes its antifreeze activity. The ... -
Speciation, Natural Selection, and Networks: Three Historians Versus Theoretical Population Geneticists
(Social Sciences Research Network, 2022-11-12)The early biometricians, who attacked Mendelism, morphed into modern population geneticists, who accept Mendelism but maintain that natural selection suffices to explain both within-species evolution ("microevolution") and ... -
Placental epigenetic modifications and development in valproic acid-induced teratogenesis
Valproic acid (VPA) is an anti-epileptic and a teratogen. In utero exposure to VPA is associated with congenital malformations and neurodevelopment disorders. VPA exerts its teratogenic effects through epigenetic dysregulation, ... -
FODMAP availability modulates the influence of the microbiota on visceral afferent neuron activation
Abdominal pain is commonly observed in gastrointestinal diseases such as irritable bowel syndrome (IBS). However, it is unclear what role the microbiota plays in the development of abdominal pain. It has been shown that ... -
Characterizing Stem Cell Antigen-1 Positive Trophoblast Cells in the Trophoblast Stem Cell Niche and Placenta Development in the Mouse
Oxygen concentration and transforming growth factor-β (TGF-β) are important for placenta development and the regulation of trophoblast cell proliferation and differentiation. Stem cell antigen-1 (Sca-1) is a cell surface ... -
Dissecting the role of mitochondrial fusion in maintaining breast cancer growth and survival
Mitochondria are dynamic organelles which serve a wide range of cellular functions such as energy production through oxidative phosphorylation, serving as a calcium storage pool controlling ionic balance and overall support ... -
Investigating the Therapeutic Efficacy of Aspirin and Oseltamivir Phosphate in Combination with Gemcitabine for the Treatment of Pancreatic Cancer
Pancreatic cancer is one of the most lethal malignancies and is often referred to as the “silent killer.” In addition to its advanced-stage detection, there have been no significant improvements in patient survival rates ... -
Genomic correlates of the tumor immune microenvironment and response to therapeutic STING pathway activation in high grade serous ovarian carcinoma
High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy, characterized by late diagnosis and high rates of recurrence. While most patients show initial sensitivity to platinum-taxane based ... -
Phenotyping the chronobiology of microglia
Chronic neuropathic pain affects 7-10% of the population and is caused by damage to the somatosensory nervous system that persist after the initial injury has healed. The development of neuropathic pain is influenced by ... -
The Role of Peroxisome Proliferator-activated Receptor γ during Breast Tumour Angiogenesis
Breast cancer remains a global health challenge as the most common cancer type worldwide and the leading cause of new cancer cases among Canadian females. Despite recent advances in early screening and targeted therapies, ... -
Characterization of the Antiviral Mechanisms of Cyclophilin Inhibitors against Coronavirus Replication
Coronaviruses (CoVs) are zoonotic positive sense RNA (+ssRNA) viruses with pandemic potential, as evidenced by the recent and ongoing SARS-CoV-2 outbreak, which has posed an incredible global health and socioeconomic burden. ... -
Characterization of the Antiviral Functions of Interleukin-27 during Dengue Virus Infection of Human Macrophages
Dengue virus (DENV) causes the most prevalent mosquito-transmitted viral disease, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), with an estimated 390 million infections and 20,000 deaths annually. ... -
Interleukin-27 Inhibition of Pandemic Influenza A Virus Infection in Human Macrophages Partially Relies on Type I IFNs.
Zoonotic reservoirs as well as high mutation rates make influenza A viruses (IAV) a looming pandemic threat. Recent studies have identified antiviral activities of the cytokine interleukin-27 (IL-27) against several viruses, ...
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