Biomedical and Molecular Sciences, Department of
The Department of Biomedical and Molecular Sciences strives to provide students with the best conditions to develop into independent, productive, research scientists in a dynamic learning environment.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
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Anatomical Sciences Graduate Projects
This collection contains Pattern II MSc in Anatomical Sciences graduate projects
Recent Submissions
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Adhesion Proteins: Keeping Bacteria in Their Place
Many bacteria produce outer membrane-localized proteins that adhere them to varying biotic and abiotic substrates. Such interactions are crucial for the life-cycle of many microorganisms, promoting retention in high-nutrient ... -
On certain two-signal perspectives of lymphocyte activation and inactivation, thymic G-quadruplexes, and the role of aggregation in self/not-self discrimination
(Wiley, 2019-06-05)Distinctive “two signal” paths in immunology, taken by researchers with different academic backgrounds, seem to have both contained facets of the truth. Having been influenced by education at a medical school where Almroth ... -
Interleukin-27 Modulates Monocyte and Macrophage Toll-Like Receptor Responses to Bacterial and Viral Components
Interleukin (IL)-27 is a heterodimeric cytokine with pleiotropic functions across both innate and adaptive immunity. Composed of subunits IL-27p28 and EBI3, IL-27 signals via a heterodimeric receptor of gp130 and WSX-1 to ... -
Investigating the Role of Neutrophils in Endometriosis Pathophysiology
Endometriosis is a debilitating gynecological disease characterized by the presence of endometrial-like tissue lesions outside of the uterus. Chronic inflammation is a hallmark feature of endometriosis, which has been ... -
Blockade of the Human Ether A-Go-Go-Related Gene (hERG) Potassium Channel by Fentanyl
Fentanyl poses a serious health concern, with abuse and death rates rising over recent years. Despite the high number of overdose deaths attributed to fentanyl, the complete molecular mechanisms of such deaths have not ... -
The use of viscoelastic hemostatic tests in pregnancy and puerperium: review of the current evidence - communication from the Women's Health SSC of the ISTH
(Wiley, 2019-05-24)Recent years have shown increasing interest in the use of thromboelastography (TEG) (Haemonetics, Braintree, MA) and thromboelastometry (ROTEM; Munich, Germany). These are established point‐of‐care global viscoelastic ... -
The Role of Recombinant Oviduct-Specific Glycoprotein (OVGP1) During Early Events of Fertilization
The mammalian oviductal secretory cells synthesize and secrete a major glycoprotein known as the oviduct-specific glycoprotein (OVGP1) which is in abundance around the time of fertilization. In vitro studies carried out ... -
Single Nucleotide Polymorphism of B-Type Natriuretic Peptide and Carotid Ultrasound Imaging as Biomarkers to Determine the Severity of Atherosclerosis
Cardiovascular disease (CVD) has been the number one cause of death in the world for several decades and will continue to worsen as a global epidemic. The underlying cause of CVD is atherosclerosis: most myocardial infarctions ... -
Catheter Ablation of Symptomatic Atrial Fibrillation: Impact on Physical Activity, Health-related Quality of Life, and Burden of Arrhythmia
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting more than 33 million individuals worldwide. AF may lead to severe complications associated with disabling symptoms that can reduce ... -
Roles of Arginase-1 in Neural Cells
Arginase-1 (ARG1) is an essential urea cycle (UC) enzyme that catalyzes the hydrolysis of arginine, proposed to also be involved in pre- and post-natal development and post-injury regeneration of neural cells. Genetic ... -
Impact of Vascular Calcification on the Regulation of Circulating Minerals and Hormones in Experimental Chronic Kidney Disease
Cardiovascular disease (CVD) is a significant concern in chronic kidney disease (CKD) accounting for over half of all mortality. The high CVD prevalence in CKD is not accounted for by traditional Framingham risk factors ... -
Zinc exposure increases resistance to polymyxins in Pseudomonas aeruginosa through activation of the arn operon and two-component regulatory systems
Metal cations have long been known to play a role in driving antibiotic resistance. The metal cation Zn2+ has previously been shown to drive antibiotic resistance in various bacterial species, including the opportunistic ... -
Aldehyde Dehydrogenase 2 Knockout Mice as a Potential Model of Vascular Cognitive Impairment and Alzheimer's Disease
Oxidative stress causes tissue damage in several models of vascular cognitive impairment (VCI) and in age-related Alzheimer’s disease (AD). We have developed a novel oxidative stress-based mouse model of age-related cognitive ... -
Biosynthesis of Prodiginine and Tambjamine Natural Products in Pseudoalteromonas Sp.
Prodiginines and tambjamines are two classes of pigmented natural products that display structural variety and hold many useful bioactivities, making them a desirable target for pharmaceutical agents. Enzymes PigC and TamQ ... -
Novel Reagents for the Determination of Calpain Activity In Vitro and In Vivo
Calpains are multi-domain intracellular Ca2+-activated cysteine proteases. They participate in a number of cellular processes downstream of calcium signaling. Unregulated calpain activity, caused by a loss of calcium ... -
Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
Phenotypic plasticity of human arterial smooth muscle cells (HASMCs) allows them to transition from a “contractile/quiescent” state, in which they regulate arterial tone and blood pressure, to one in which these cells are ... -
A NMR Study of the Cellulosome Dockerin:Cohesin Dual Binding Mode
The recalcitrant nature of the carbon-rich plant cell wall is largely owed to its array of structural polysaccharides, which are efficiently hydrolyzed by the anaerobic bacterium Clostridium thermocellum via a multi-enzyme ... -
Lipid signalling modulates neuroendocrine cell excitability and cation channel function
Ion channel function and modulation determine the strength and duration of periods of enhanced neuronal activity and excitability that control and shape behaviour. The bag cell neurons of the hermaphroditic sea snail, ... -
Characterization of the interactions of a lignostilbene alpha-beta dioxygenase with both stilbene and carotenoid substrates
As one of many evolutionary compensations for immobility, plants synthesize an array of natural products and metabolites which afford advantage against environmental stresses. The utility of these products is exemplified ... -
Induction of Immune Tolerance to Hexosaminidase M Using Rapamycin and Prednisone in the scAAV9-HEXM Gene Therapy Treatment of Sandhoff Disease
Sandhoff disease (SD) is a neurodegenerative disorder caused by the toxic accumulation of GM2 gangliosides in the brain. This is due to a deficient enzyme, β-hexosaminidase A (HEXA), involved in the catabolism of GM2 ...
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