Biomedical and Molecular Sciences, Department of
The Department of Biomedical and Molecular Sciences strives to provide students with the best conditions to develop into independent, productive, research scientists in a dynamic learning environment.
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Collections in this community
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Anatomical Sciences Graduate Projects
This collection contains Pattern II MSc in Anatomical Sciences graduate projects
Recent Submissions
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INVESTIGATING THE ROLES OF HERPES SIMPLEX VIRUS TYPE 2 PROTEINS UL21 AND US3 IN REGULATION OF THE NUCLEAR EGRESS COMPLEX
Herpes Simplex Virus 2 (HSV-2) nuclear egress is mediated by viral nuclear egress complex (NEC) proteins, pUL31 and pUL34, found at the inner nuclear membrane of infected cells (INM). Nuclear egress requires successful ... -
CHARACTERIZATION OF THE AGE-DEPENDENT CHANGES IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS
Biological aging leads to a reduced capacity of hematopoietic stem/progenitor cells (HSPCs) to efficiently produce blood and immune cells, which contributes to various age-related pathologies. Further understanding of this ... -
TRANSLATIONAL CHARACTERIZATION OF ACUTE PHOSPHATE DISPOSITION AS IT RELATES TO BONE AND MINERAL HOMEOSTASIS AND CHRONIC KIDNEY DISEASE
Elevated serum phosphate is an independent risk factor for cardiovascular disease (CVD) in the general population, and this elevated risk is most prominent in the setting of chronic kidney disease (CKD). Dysregulation of ... -
EXAMINATION OF CBP/P300/AKT, NF-ΚB AND STAT3 SIGNALING FOLLOWING IN UTERO VALPROIC ACID EXPOSURE IN CD-1 MOUSE EMBRYOS WITH NEURAL TUBE DEFECTS
Valproic acid (VPA), an antiepileptic drug and effective treatment for mood disorders is teratogenic with an increased risk of congenital malformations including neural tube defects (NTDs) following in utero exposure. The ... -
Investigating bacterial adhesion proteins as tools for controlling bacteria-surface interactions
Adhesins are cell-surface proteins that initiate target binding and surface colonization by bacteria on the path to infection and biofilm formation. A deeper understanding of the interactions between adhesins and their ... -
Characterization of Molecular Partners of the Programmed Death (PD)-1/Programmed Death Ligand (PD-L)1 Immune Checkpoint
Since its discovery, the Programmed Death (PD)-1/Programmed Death-Ligand (PD-L)1 immune checkpoint has been an area of interest in cancer research due to its role in conferring immune escape to tumour cells. Most research ... -
PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
Most studies on the Programmed Death 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) immune checkpoint have focused on elucidating the signaling mechanisms leading to inactivation of immune effectors. We, along with others, ... -
The Role of Macrophages and the NLRP3 Inflammasome In Right Ventricular Failure in Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is an obliterative pulmonary vasculopathy that results in right ventricular failure (RVF). We speculate that RVF results from inflammation due to the influx of inflammatory ... -
NEURONAL OXIDATIVE STRESS AND DENDRITIC TRIMMING IN A MOUSE MODEL OF LATE ONSET ALZHEIMER`S DISEASE
The study of late-onset (sporadic) Alzheimer`s Disease (LOAD) has lacked animal models where the impairments develop with aging. Oxidative stress promotes LOAD, so we have developed an oxidative stress-based model of ... -
Investigating Embryonic Gene Expression Changes in a Rat Model of Congenital Heart Defects and Longitudinal Effects on Postnatal Cardiac Structure and Function
Congenital heart defects (CHD) are the most common birth defect, occurring in approximately 1% of all births and continue to be a significant cause of infant morbidity and mortality. Ventricular septal defects (VSD) account ... -
CHARACTERIZING THE ANTIVIRAL PROPERTIES OF M2A MACROPHAGES
Macrophages (Mφ) are innate immune sentinels that can acquire highly heterogeneous phenotypes depending on their cytokine microenvironment. Mφ exhibit distinct activation patterns across a continuum from pro-inflammatory ... -
Placental morphology and the prediction of underlying cardiovascular risk factors
Pre-eclampsia (PE) is associated with an increased risk of future cardiovascular disease (CVD). It is characterized by new-onset hypertension and proteinuria, sometimes progressing into a multiorgan clinical manifestation. ... -
Repeats-In-Toxin Adhesion Proteins: What Makes Them Stick?
Bacteria use adhesion proteins (adhesins) to bind substrates on biotic and abiotic surfaces to initiate biofilm formation. These bacterial communities can be detrimental to a host when, for example, they cause teeth plaques, ... -
The Role of Muscarinic M2 and M3 Receptor Subtypes in Cardiopulmonary Responsiveness: Insights from In Vivo Murine Models
Muscarinic receptors play an important role in cholinergic transmission and physiologic events. However, the study of the mechanisms by which muscarinic receptors mediate cardiopulmonary responses have been hampered by the ... -
Bioinformatics Approaches for Investigating Missing Heritability in Complex Traits
Advancements in high-throughput technologies and high-performance computing have enabled the discovery of tens of thousands of genetic associations for complex traits and diseases. However, these associations explain only ... -
Neurophysiology of Exertional Dyspnea in Interstitial Lung Disease and Pulmonary Vascular Disease: Final Common Pathways
Dyspnea is an important symptom that negatively impacts quality of life and results in functional limitation and disability. The overarching objective of this thesis was to explore mechanisms of chronic activity-related ... -
Characterizing the Development of Secondary Hyperparathyroidism and Vitamin D Resistance in Experimental Chronic Kidney Disease
The parathyroid gland (PTG) responds to alterations in calcium and phosphate via secretion of parathyroid hormone (PTH) that acts on kidneys and bone to regulate mineral homeostasis. Hallmarks of chronic kidney disease ... -
Developing Synthetic Actin Toxins for the Treatment of Metastatic Cancers
Metastasis is the leading cause of cancer related deaths and new therapies that disrupt the metastatic process are urgently needed. The actin cytoskeleton is very dynamic structure required for cancer cell invasion and ... -
Characterization of GM- and M-CSF-Derived Macrophages Response to Lymphocytic Choriomeningitis Virus Infection and TLR7 Agonist
Macrophages (MΦ) are innate immune cells considered as the primary line of defense during infection and as controllers of tissue homeostasis. In response to viral infection, MΦ induce cytokine production and regulate ... -
Investigating the Receptor Interactions and Mechanisms of a Folic Acid-Conjugated Nanoparticle in the Treatment of Breast Cancer
An area of intense research focus is the development of a highly specific drug delivery system (DDS) for anti-cancer agents. Chemical engineering of a “smart” DDS to specifically target tumor cells has gained interest in ...
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