Browsing Biomedical and Molecular Sciences, Department of by Title
Now showing items 388-407 of 415
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STRUCTURE-GUIDED STUDIES OF BACTERIAL COMPETITION MECHANISMS
(2015-12-16)Microorganisms have evolved a stunning array of strategies for nutrient competition, ranging from concerted effort of antibiotic release to kill off competing species, to evolving complex enzymatic pathways that are capable ... -
Studies of Coagulation and Fibrinolysis
(2009-09-04)The mechanism and regulation of prothrombinase function in the activation of prothrombin and prethrombin-1 were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism ... -
Studies of the Misprocessing Mutations R1202D and E1204K in the Drug and Organic Anion Transporter, MRP1 (ABCC1) in Cultured HEK cells
(2013-11-19)Multidrug resistance protein 1 (MRP1) is a drug and organic anion transporter of the ATP-binding cassette superfamily. Previous studies showed that opposite charge substitutions of Arg1202 or Glu1204 in transmembrane helix ... -
STUDIES ON DICTYOSTELIUM DISCOIDEUM MYOSIN-I AND MYOSIN-II HEAVY CHAIN KINASES
(2013-08-21)PakB is a p21-activated kinase that phosphorylates and activates class I myosins in the social amoeba Dictyostelium discoideum. PakB co-localizes with myosin-I to actin-rich regions of the cell, including macropinocytic ... -
A study of mechanisms underlying inflammation-induced abnormal nociceptive signaling from the colon in models of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)
(2011-08-10)Abdominal pain is a common symptom of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Although the extent differs, visceral inflammation is thought to play a significant role in nociception in these ... -
A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
(2012-09-08)Chronic abdominal pain is a major cause of patient morbidity in inflammatory bowel diseases (IBD). A balance of pro- and anti-nociceptive factors regulating colonic dorsal root ganglion (DRG) neurons, which synapse onto ... -
A Study of the Roles of Selected Arginine and Lysine Residues of TAFI in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex
(2008-02-01)Thrombin-activatable Fibrinolysis Inhibitor (TAFI) is a 60 kDa plasma protein that can be activated to the enzyme, TAFIa, by thrombin, plasmin or trypsin. TAFIa is a carboxypeptidase B-like enzyme that attenuates fibrinolysis. ... -
THE SUBFORNICAL ORGAN AND AREA POSTREMA MEDIATE THE CENTRAL EFFECTS OF CIRCULATING LEPTIN
(2012-10-15)Leptin is an adipokine that acts centrally to regulate feeding behaviour, energy expenditure and autonomic function via activation of its receptor (ObRb) in nuclei in the central nervous system (CNS). This thesis investigates ... -
The Subfornical Organ: An Integrative Site for Reproductive, Cardiovascular, and Metabolic Control
(2016-04-20)In order to maintain homeostasis, the central nervous system (CNS) must monitor and integrate signaling molecules such as peptides and hormones that convey information regarding reproductive, metabolic, and cardiovascular ... -
Susceptibility of the hERG Potassium Channel to Proteases and its Clinical Implications
Cardiovascular diseases are the leading cause of death worldwide. Cardiac ischemia accounts for approximately 50% of all cardiovascular-related deaths. Cardiac ischemia is associated with high incidence of QT prolongation ... -
Systemic Vascular Dysfunction in Patients with Mild Chronic Obstructive Pulmonary Disease
Background: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of cardiovascular disease, a finding that might be mechanistically linked to systemic vascular abnormalities. In fact, coexistent ... -
Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
(2016-10-03)Breast and ovarian cancers are among the leading causes of cancer related deaths in women worldwide. In a subset of these cancers, dysregulation of the human epidermal growth factor receptor 2 (HER2) leads to overexpression ... -
THROMBOSPONDIN-1 ANALOG, ABT-898, INHIBITS ENDOMETRIOTIC LESION VASCULARIZATION WITHOUT AFFECTING FERTILITY OR PREGNANCY OUTCOMES IN A MURINE MODEL OF ENDOMETRIOSIS
(2013-05-22)Endometriosis is a gynecological disease defined as the growth of endometrium outside of the uterus. Although linked to 50% of female infertility cases, current medical treatments fail to maintain fecundity. Since the ... -
Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
(2009-04-22)Thymoquinone (TQ), a volatile oil component of black seed oil (derived from Nigella sativa), has been shown to have various biological effects including disease treatment and prevention. TQ is believed to share similar ... -
The Transcription Factor NFIL3 Is Not Required For Uterine Natural Killer Cell Differentiation But Contributes To Placental And Conceptus Development
(2015-09-26)Uterine natural killer (uNK) cells are the most abundant lymphocyte in early human and mouse decidua. UNK cell functions have been deduced by histopathologic comparisons of implantation sites between alymphoid (NK-T-B-), ... -
TRANSIENT LIPOPOLYSACCHARIDE-INDUCED CYTOKINE RESPONSES IN THE MATERNAL AND FETAL GUINEA PIG
(2007-11-29)The aim of this study was to further investigate the role of pro-inflammatory cytokines in the pathogenesis of fetal cererbral white matter injury associated with chorioamnionitis by charaterizing the time course of the ... -
The type I antifreeze protein gene family in Pleuronectidae
(2009-02-02)Antifreeze proteins (AFPs) protect marine teleosts from freezing in icy seawater by binding to nascent ice crystals and preventing their growth. It has been suggested that the gene dosage for AFPs in fish reflects the ... -
UNDERSTANDING THE MECHANISM OF MOTILITY OF THE HETERODIMERIC KINESIN-14 KAR3VIK1
(2013-07-23)The kinesin-14 Kar3 from Saccharomyces cerevisiae (Sc) is a C-terminal motor that forms a heterodimer with the kinesin-accessory protein Vik1. Although Vik1 possesses a typical kinesin motor domain (MD) fold, it lacks a ... -
THE UNLIGANDED GLUCOCORTICOID RECEPTOR AS A TRANSCRIPTIONAL REGULATOR IN MAMMARY EPITHELIAL CELLS
(2012-12-03)This work presents the first evidence of a ligand-independent role for the glucocorticoid receptor (GR) as a positive regulator of gene expression in mammary cells. We have demonstrated that unliganded GR interacts directly ... -
Up-regulation of HO-1 attenuates left ventricular remodeling post myocardial infarction in rats
(2007-10-03)Background/Objective: Reperfusion injury is a serious consequence of blood flow reestablishment after myocardial infarction (MI) mediated by reactive oxygen species and neutrophilic cellular damage. Following MI, the left ...