Browsing Biomedical and Molecular Sciences, Department of by Title
Now showing items 408-427 of 431
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A Study of the Roles of Selected Arginine and Lysine Residues of TAFI in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex
(2008-02-01)Thrombin-activatable Fibrinolysis Inhibitor (TAFI) is a 60 kDa plasma protein that can be activated to the enzyme, TAFIa, by thrombin, plasmin or trypsin. TAFIa is a carboxypeptidase B-like enzyme that attenuates fibrinolysis. ... -
The Subfornical Organ and Area Postrema Mediate the Central Effects of Circulating Leptin
(2012-10-15)Leptin is an adipokine that acts centrally to regulate feeding behaviour, energy expenditure and autonomic function via activation of its receptor (ObRb) in nuclei in the central nervous system (CNS). This thesis investigates ... -
The Subfornical Organ: An Integrative Site for Reproductive, Cardiovascular, and Metabolic Control
(2016-04-20)In order to maintain homeostasis, the central nervous system (CNS) must monitor and integrate signaling molecules such as peptides and hormones that convey information regarding reproductive, metabolic, and cardiovascular ... -
Susceptibility of the hERG Potassium Channel to Proteases and its Clinical Implications
Cardiovascular diseases are the leading cause of death worldwide. Cardiac ischemia accounts for approximately 50% of all cardiovascular-related deaths. Cardiac ischemia is associated with high incidence of QT prolongation ... -
Systemic Vascular Dysfunction in Patients with Mild Chronic Obstructive Pulmonary Disease
Background: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of cardiovascular disease, a finding that might be mechanistically linked to systemic vascular abnormalities. In fact, coexistent ... -
Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
(2016-10-03)Breast and ovarian cancers are among the leading causes of cancer related deaths in women worldwide. In a subset of these cancers, dysregulation of the human epidermal growth factor receptor 2 (HER2) leads to overexpression ... -
These Motors Were Made for Walking
(Wiley, 2020-05-29)Kinesins are a diverse group of ATP‐dependent motor proteins that transport cargos along microtubules (MTs) and change the organization of MT networks. Shared among all kinesins is a ~ 40 kDa motor domain that has evolved ... -
Thrombospondin-1 Analog, ABT-898, Inhibits Endometriotic Lesion Vascularization Without Affecting Fertility or Pregnancy Outcomes in a Murine Model of Endometriosis
(2013-05-22)Endometriosis is a gynecological disease defined as the growth of endometrium outside of the uterus. Although linked to 50% of female infertility cases, current medical treatments fail to maintain fecundity. Since the ... -
Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
(2009-04-22)Thymoquinone (TQ), a volatile oil component of black seed oil (derived from Nigella sativa), has been shown to have various biological effects including disease treatment and prevention. TQ is believed to share similar ... -
The Transcription Factor NFIL3 Is Not Required For Uterine Natural Killer Cell Differentiation But Contributes To Placental And Conceptus Development
(2015-09-26)Uterine natural killer (uNK) cells are the most abundant lymphocyte in early human and mouse decidua. UNK cell functions have been deduced by histopathologic comparisons of implantation sites between alymphoid (NK-T-B-), ... -
Transient Lipopolysaccharide-Induced Cytokine Responses in the Maternal and Fetal Guinea Pig
(2007-11-29)The aim of this study was to further investigate the role of pro-inflammatory cytokines in the pathogenesis of fetal cererbral white matter injury associated with chorioamnionitis by charaterizing the time course of the ... -
The type I antifreeze protein gene family in Pleuronectidae
(2009-02-02)Antifreeze proteins (AFPs) protect marine teleosts from freezing in icy seawater by binding to nascent ice crystals and preventing their growth. It has been suggested that the gene dosage for AFPs in fish reflects the ... -
Understanding the Mechanism of Motility of the Heterodimeric Kinesin-14 KAR3VIK1
(2013-07-23)The kinesin-14 Kar3 from Saccharomyces cerevisiae (Sc) is a C-terminal motor that forms a heterodimer with the kinesin-accessory protein Vik1. Although Vik1 possesses a typical kinesin motor domain (MD) fold, it lacks a ... -
The Unliganded Glucocorticoid Receptor as a Transcriptional Regulator in Mammary Epithelial Cells
(2012-12-03)This work presents the first evidence of a ligand-independent role for the glucocorticoid receptor (GR) as a positive regulator of gene expression in mammary cells. We have demonstrated that unliganded GR interacts directly ... -
Up-regulation of HO-1 attenuates left ventricular remodeling post myocardial infarction in rats
(2007-10-03)Background/Objective: Reperfusion injury is a serious consequence of blood flow reestablishment after myocardial infarction (MI) mediated by reactive oxygen species and neutrophilic cellular damage. Following MI, the left ... -
Us3 disrupts PML nuclear bodies through its interaction with KLHL21 to promote viral gene transcription in interferon-exposed cells
(2014-04-28)Us3, a serine/threonine kinase encoded by all alphaherpesviruses, plays diverse roles during virus infection. Recently, work done in our laboratory determined that Us3 orthologues from herpes simplex type 2 (HSV-2) and ... -
The use of viscoelastic hemostatic tests in pregnancy and puerperium: review of the current evidence - communication from the Women's Health SSC of the ISTH
(Wiley, 2019-05-24)Recent years have shown increasing interest in the use of thromboelastography (TEG) (Haemonetics, Braintree, MA) and thromboelastometry (ROTEM; Munich, Germany). These are established point‐of‐care global viscoelastic ... -
Using a Novel Complexity-based Human Dissection Course for Complementary and Alternative Medicine Practitioners of Physical Manipulation: Utility and Effect on Clinical Practice
Background and Purpose: There will always be a discrepancy between theory and practice. The coevolution of the theory and practice of anatomy has become more difficult with the passage of time, and the advancement of ... -
Vagal Integration of Cardiopulmonary Regulation
(2015-10-01)Cardiopulmonary control relies on local and central integration of sensory inputs and reflex efferent signaling. Heart and lung sensors, integrators, and effectors are routinely studied in a reductionist manner to elucidate ... -
Ventilatory constraints and breathlessness during exercise in the elderly, in the obese, and in those with mild airflow limitation
(2008-07-08)Breathlessness during activity is increasingly recognized as a common symptom in the elderly, in older individuals with minor airway obstruction due to tobacco smoking, and in those with obesity. The underlying mechanisms ...