Browsing Biomedical and Molecular Sciences, Department of by Title
Now showing items 45-64 of 419
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Characterization and Modulation of Electrical Coupling Between Molluscan Neuroendocrine Cells
(2014-07-23)The bag cell neurons of Aplysia initiate reproductive behaviour by secreting egg-laying hormone during a prolonged period of synchronous and repetitive firing known as the afterdischarge. Electrical coupling facilitate the ... -
Characterization of a Newly Synthesized Cysteinyl Leukotriene 2 Receptor Selective Antagonist Using Cell Based β-arrestin and Vascular Ear Permeability Assays in Mice
(2011-07-06)(hCysLT2R) based on a β-galactosidase complementation system. The EC50 values for LTC4 and LTD4 are consistent with previous literature values determined based on radio-labelling affinity assays for hCysLT2R. Activity ... -
Characterization of a shigella boydii B14 galactosyltransferase involved in O-antigen synthesis
(2010-09-24)The O-antigenic glycan chains (O-antigen) of lipopolysaccharides (LPS) in Gram-negative bacteria are synthesized by glycosyltransferases (GTs), most of which are yet to be characterized. The LPS are important for cell ... -
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
(2012-09-26)Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ... -
Characterization of Karyopherin Alpha's Relationship with SubH2Bv as Acrosome-Associated Proteins in Spermiogenesis
(2008-09-04)Specialized in form and function, the sperm cell is a unique microsystem unto itself where in the cytoskeletal processes and structures of the somatic cell often find new purpose and characteristics within the sperm. ... -
Characterization of NfxB and PA4596, Two Repressors of the mexCD-oprJ Operon Encoding an RND-Type Multidrug Efflux Pump in Pseudomonas aeruginosa
(2013-06-12)MexCD-OprJ is an RND-type multidrug efflux pump present in P. aeruginosa and is capable of exporting, and as such providing resistance to, several clinically important antimicrobials including fluoroquinolones, cephems, ... -
Characterization of TAFI Activation by the Thrombin-Thrombomodulin Complex
(2015-01-21)Once activated, protein C (PC) and thrombin-activable fibrinolysis inhibitor (TAFI) initiate anticoagulant and anti-fibrinolytic pathways, respectively. PC and TAFI are activated by the thrombin-thrombomodulin (TM) complex. ... -
Characterization of the Alphaherpesvirus Tegument Protein US2
(2013-01-21)Members of the Herpesviridae are large enveloped, double-stranded DNA viruses, whose virions are comprised of a viral genome-containing icosahedral capsid, a layer of tegument and a glycoprotein-embedded envelope. The ... -
Characterization of the Baculovirus Late Expression Factor-3 Oligomerization Interaction Domains Using Protein Complementation Assay
(2011-05-27)Late expression factor 3 is one of the six AcMNPV genes essential for DNA replication identified through transient replication assays. LEF-3 is a single stranded DNA binding protein responsible for the transportation of ... -
Characterization of the Human Atypical Kinase, aarf Domain-Containing Kinase 3, and its Substrates Required for Coenzyme Q biosynthesis
Aarf domain-containing kinase 3, ADCK3, is a human atypical protein kinase located in the inner membrane of the mitochondria that is required for the biosynthesis of coenzyme Q (CoQ). Stable supply of CoQ is essential to ... -
Characterization of the interactions of a lignostilbene alpha-beta dioxygenase with both stilbene and carotenoid substrates
As one of many evolutionary compensations for immobility, plants synthesize an array of natural products and metabolites which afford advantage against environmental stresses. The utility of these products is exemplified ... -
Characterization of the interactions of baculovirus transcription and replication regulators by bimolecular fluorescence complementation
(2014-12-01)Baculovirus gene expression is temporally divided into early and late stages. Viral late expression factors (LEFs) are essential for the transition between the early and late transcriptional stages, as well as for late ... -
Characterization of the MexT Regulator of the mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa
(2011-05-16)Pseudomonas aeruginosa is resistant to many clinically-relevant antibiotics and this is partly attributable to multidrug efflux systems in this organism. One of these, MexEF-OprN, exports chloramphenicol, fluoroquinolones ... -
Characterization of Valproic Acid-Initiated Homologous Recombination
(2009-08-12)Oxidative stress and histone deacetylase (HDAC) inhibition has been implicated as potential mechanisms in valproic acid (VPA) teratogenicity. Reactive oxygen species (ROS) can target DNA to cause oxidative DNA damage and ... -
Characterization of Vascular Calcification in a Rodent Model of Chronic Kidney Disease
(2009-12-17)Chronic kidney disease (CKD) is a worldwide health problem with rising incidence and high cardiovascular mortality. CKD compromises cardiovascular function, in part, characterized by vascular calcification (VC), elevated ... -
Characterization of γδ T cells in Peripheral Nociception and Inflammatory Pain Hypersensitivity
Inflammatory pain can occur following tissue insult, bacterial infection, arthritis and various autoimmune diseases and is initiated and maintained by a well-orchestrated response of recruited and tissue-resident immune ... -
Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
Many antiepileptic drugs on the market, including valproic acid (VPA), have a wide range of therapeutic effects in addition to treating epilepsy. In recent years, the use of VPA in the treatment of psychiatric conditions ... -
Characterizing the Functional Domains of the Baculovirus Late Expression Factor 3 (LEF-3) Involved in Nuclear Localization and DNA Replication
(2009-01-05)Transient replication assays have identified a late expression factor 3, LEF-3, to be essential for DNA replication and late gene expression in the baculovirus species, AcMNPV. Although its specific role in these two ... -
Characterizing the Role of the Herpes Simplex Virus Type 2 UL21 Protein in Viral Nuclear Egress
(2015-07-17)The herpes simplex virus type 2 (HSV-2) is an important human pathogen that is the main cause of genital herpes infections and has a significant and wide-ranging impact on human health. HSV-2 infections are one of the most ... -
Characterizing Valproic Acid-Induced DNA Double Strand Break Repair
(2012-10-15)The teratogenic effects of valproic acid (VPA) are well known, though its teratogenic mechanism remains unknown. VPA induces oxidative stress, which may lead to double strand breaks (DSBs) in DNA. Though the cell may repair ...